Hypospadias results from a failure of urethral closure in the male phallus and affects 1 in 200-300 boys. It is thought to be due to a combination of genetic and environmental factors. The development of the penis progresses in 2 stages: an initial hormone-independent phase and a secondary hormone-dependent phase. Here, we review the molecular pathways that contribute to each of these stages, d...

Penile reconstruction is usually performed in patients with gender dysphoria; with penile loss because of trauma, infection, and tumors; and with congenital deformities like severe hypospadias, in which standard techniques do not achieve a good result. Hypospadias are one of the most common inherent genital anomalies in boys. Many surgical procedures have been published for total phallic recons...

background: hypospadias is one of the most common congenital abnormalities in the male which is characterized by altered development of urethra, foreskin and ventral surface of the penis. androgen receptor gene plays a critical role in the development of the male genital system by mediating the androgens effects. objective: in present study, we looked for new variations in androgen receptor pro...

Hypospadias is a congenital anomaly of the male urethra that causes significant morbidity in the pediatric male population. The mainstay of treatment is hypospadias repair surgery. However, given the common co-occurrence of microphallus in these patients, surgery remains difficult without adequate tissue for proper reconstruction of the urethra. The use of preoperative testosterone therapy, par...

The original report published in 2001 on a possible association between maternal use of loratadine and an increased risk of infant hypospadias, based on data in the Swedish Medical Birth Register 1995-2001, has been followed up by continued surveillance in the same register. The original "signal" was based on 15 infants with hypospadias among 2780 loratadine-exposed infants born, representing a...

Most techniques for treatment of balanitic hypospadias cannot be considered entirely satisfactory because they are too complex, necessitate several repair procedures or involve complications such as fistulas, strictures and necrosis. Because of these circumstances and because of the possibility of poor results, most surgeons believe that correction of this condition is not necessary since mictu...

operation techiniques have been described for the surgical treatment of primary hypospadias. The objective to be attained in all these methods is to ensure the formation of a functionally normal urethra and a cosmetically acceptable penis. Functional integrity was used to be important in the first years of hypospadias surgery which was then popular (1). Multi-staged repair methods have been des...

introduction: in order to assess our skill in the tubularized incised plate (tip) urethroplasty technique in children with hypospadias. material andmethods: of 307 children (mean age 38 month) who received a tip urethroplasty, all had primary hypospadias. patients who were referred with complication were eliminated from our study. the hypospadias defects were subcoronal in 25 (8%), distal penil...

A retrospective clinical trial was performed to evaluate the incidence, clinical characteristics, diagnosis and treatment methods of abnormal prostatic utricle configuration (APUC) in hypospadias and intersex patients. Forty-five hypospadias and 72 intersex patients in whom the configuration of prostatic utricle (PU) was evaluated by radiological and endoscopic investigations formed the study g...

BACKGROUND Exposure to perfluorooctane sulfonate (PFOS) may potentially disturb fetal Leydig cell hormone production and male genital development. OBJECTIVES We aimed to study the associations between levels of amniotic fluid PFOS, fetal steroid hormone, and insulin-like factor 3 (INSL3) and the prevalence of cryptorchidism and hypospadias. METHODS Using the Danish National Patient Registry...