GABRIEL OLVEIRA, PHD MAR IA JOSÉ TAPIA, MD JULIA OCÓN, PHD CARMEN CABREJAS-GÓMEZ, MD MAR IA D. BALLESTEROS-POMAR, PHD ALFONSO VIDAL-CASARIEGO, MD CARMEN ARRAIZA-IRIGOYEN, MD JOSEFINA OLIVARES, MD MARIA DEL CARMEN CONDE-GARC IA, PHD ALVARO GARC IA-MANZANARES, MD FRANCISCO BOTELLA-ROMERO, PHD ROSA P. QU ILEZ-TOBOSO, MD LUCIO CABRERIZO, PHD PILAR MATIA, MD LUISA CHICHARRO, MD ROSA BURGOS, PHD PEDR...

IA-2 is a major autoantigen in type 1 diabetes. Autoantibodies to IA-2 appear years before the development of clinical disease and are being widely used as predictive markers to identify individuals at risk for developing type 1 diabetes. IA-2 is an enzymatically inactive member of the transmembrane protein tyrosine phosphatase family and is an integral component of secretory granules in neuroe...

IA-2 and phogrin are tyrosine phosphatase-like proteins that may mediate interactions between secretory granules and cytoskeleton in islets and neuroendocrine tissues. We investigated factors that regulate IA-2 and phogrin expression and their relationship to maturation of insulin secretory responses that occur after birth. Islet content of IA-2, but not phogrin, increased during the first 10 d...

Insulinoma-associated protein 2 (IA-2) is the major autoantigen that contributes to the pathogenesis of type 1 diabetes (T1D). IA-2-deficient (IA-2-/-) mice showed impaired insulin secretion after intraperitoneal injection of glucose as well as elevated glucose level in a glucose tolerance test. Despite the fact that 70% of newly diagnosed T1D patients have an antibody against IA-2, the role of...

BACKGROUND Intracranial aneurysm (IA) is a common vascular disorder that frequently leads to fatal vascular rupture. Although various acquired risk factors associated with IA have been identified, the hereditary basis of IA remains poorly understood. As a result, genetically modified animals accurately modeling IA and related pathogenesis have been lacking, and subsequent drug development has b...

Recent studies of low redshift type Ia supernovae (SN Ia) indicate that half explode from less than Chandrasekhar mass white dwarfs, implying ignition must proceed from something besides the canonical criticality of Chandrasekhar mass SN Ia progenitors. We show that 1-100 PeV mass asymmetric dark matter, with imminently detectable nucleon scattering interactions, can accumulate to the point of ...

OBJECTIVES To evaluate the usefulness of the information obtained with SPECT, coronary angio-CT and fusion images, in patients with stable ischemic disease who need invasive coronary angiography (IA). MATERIAL AND METHODS Forty-six patients (65.98±8.3 years) with coronary disease were prospectively included. The fusion images generated after undergoing IA were used to evaluate the performance...

The morphology of filamentous fungi closely correlates with the productivity in submerged culture. Using itaconic acid (IA) production by Aspergillus terreus as a research model, the quantitative relationship between the growth form of A. terreus and IA production was investigated. IA fermentation was scaled up from shake flasks to a 7 L stirred tank bioreactor based on the quantitative relatio...

We have solved the crystal structure of the MHCII molecule, IA(b), containing an antigenic variant of the major IA(b)-binding peptide derived from the MHCII IEalpha chain. The four MHC pockets at p1, p4, p6, and p9 that usually bind peptide side chains are largely empty because of alanines in the peptide at these positions. The complex is nevertheless very stable, apparently because of unique a...

IA-32 Execution Layer (IA-32 EL) is a new technology that executes IA-32 applications on Intel® Itanium® processor family systems. Currently, support for IA-32 applications on Itanium-based platforms is achieved using hardware circuitry on the Itanium processors. This capability will be enhanced with IA-32 EL—software that will ship with Itanium-based operating systems and will convert IA-32 in...