Abl tyrosine kinase (Abl) regulates axon guidance by modulating actin dynamics. Abelson interacting protein (Abi), originally identified as a kinase substrate of Abl, also plays a key role in actin dynamics, yet its role with respect to Abl in the developing nervous system remains unclear. Here we show that mutations in abi disrupt axonal patterning in the developing Drosophila central nervous ...

BACKGROUND Measurement of the ankle-brachial index (ABI) is recommended as a screening test for cardiovascular risk prediction in individuals > or = 50 years old; however, there is little data regarding the utility of the ABI as a screening test in individuals for whom physicians actually order non-invasive testing for cardiovascular risk prediction. METHODS This study included 493 consecutiv...

The ankle-brachial index (ABI), defined as the ratio of systolic pressure in the ankle arteries and that in the brachial artery, was a useful noninvasive method to detect arterial stenoses. There had been a lot of researches about clinical regularities of ABI; however, mechanism studies were less addressed. For the purpose of a better understanding of the correlation between vascular stenoses a...

AIMS The role of low ankle-brachial index (ABI) in early-stage chronic kidney disease (CKD) is not fully known. This study was designed to investigate the prevalence of low ABI in early-stage CKD defined as an estimated glomerular filtration rate (eGFR) between 60-89 ml/min/1.73 m2 of type 2 diabetic patients without albuminuria and to determine the association between the low ABI and mildly de...

Dear Editor, We would like to call the readers’ attention to a brief communication published in the issue of January 2012, which concluded increased prevalence of left ventricular hypertrophy in subjects with an abnormal ankle brachial index (ABI). In their study, Albuquerque et al.1 compared subjects with arterial hypertension with and without an abnormal ABI. Since the prevalence of a low ABI...

OBJECTIVE To determine the association between an abnormal ankle brachial index (ABI) and the presence of significant coronary artery disease (CAD) on coronary angiography. STUDY DESIGN Cross-sectional, observational study. PLACE AND DURATION OF STUDY The study was carried out at Sheikh Zayed Hospital, Lahore, from July to October 2007. METHODOLOGY A series of 41 patients undergoing coron...

BACKGROUND The ankle-brachial pressure index (ABI), the ratio of the systolic blood pressure of the ankle to the systolic brachial pressure, is commonly measured at rest, but ABI values post-exercise enhance the sensitivity of the test and can be used to identify atherosclerotic vascular damage. However, it has not been established whether or not enhanced post-exercise ABI is also associated wi...

BACKGROUND Very little is known about the prevalence of acquired brain injury (ABI) in Ireland. ABI prevalence has previously been obtained from Belgian general practitioners using a postal survey. We attempted to ascertain the prevalence of ABI in County Mayo through a postal survey of all general practitioners in the county.The specific objectives of this project were to:1. identify whether g...

Latar belakang: Lansia adalah seseorang yang sudah memasuki usia 60 tahun keatas. rentan mengalami beberapa masalah kesehatan vaskular seperti, hipertensi, stroke, diabetes melitus dan jantung koroner terpengaruh oleh keterlambatan regeneratif yaitu fisik, kognitif bahkan emosional. Salah satu metode untuk mendeteksi gangguan ini Ankle Brachial Index (ABI). (ABI) direkomendasikan diagnosis peny...