The irritation effects of ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID), were evaluated on mouse gastric and duodenal mucosa when suspended in 0.5% (w/v) sodiumcarboxymethylcellulose (NaCMC) solution and loaded in alginate beads. The ionotropic gelation method was used to prepare controlled release alginate beads of ibuprofen. The influence of various formulation factors...

It is now 50 years since the first discovery by Dr (now Professor) Stewart Adams (of the Boots Pure Drug Company, Nottingham, UK) of the pharmacological effects of the non-steroidal anti-inflammatory drug (NSAID), ibuprofen, in a guinea pig model of skin inflammation. It is now over 40 years since this drug was introduced into clinical use at doses of 1800–2400 mg ⁄ d for the treatment of arthr...

Successful local anesthesia is the bedrock of pain control in endodontics. Pain control is essential to reduce fear and anxiety associated with endodontic procedure. It is belivied that premedication with non-streroidal anti–inflammatory (NSAID) drugs before administrating inferior alveolar nerve block (IANB) increases the success of anesthesia. The purpose of this study was to evaluate t...

Background Non-Steroidal Anti-Inflammatory Drugs(NSAIDs) including Ibuprofen is one of the most currently used drugs in all age groups and finding the relation between upper gastrointestinal bleeding and Helicobacter pylori (H. pylori) in children who used Ibuprofen, is our topic of research. Materials and Methods During the two years of the study, ten children with upper GI bleeding after Ibup...

Separation of a racemic mixture of ibuprofen at a low concentration level by supercritical fluid chromatography in a simulated moving bed (SFC-SMB) is investigated by simulation. The feasibility of ibuprofen enantiomers separation has been experimentally examined in the literature. Our simulation results show that separation of ibuprofen enantiomers is feasible by this method, and R-ibuprofen a...

Background: Pain after periodontal flap surgery is very common and its control is very important during treatment. Although Ibuprofen is the most common used drug for the pain control in dentistry, it has its own side effects. Purpose: This study was aimed to compare the prophylactic and post operation effect of the ginger Zingiber Officinale (Zintoma) and Ibuprofen on the pain after surgical ...

Emerging contaminant in drinking water has created concerns among public, water supplier and government. Pharmaceutical in water and food even in low concentration have shown potential risks to human. Acetaminophen and ibuprofen are among a set of the most prescribed drugs in the world. In this study raw water and treated drinking water from Latyan drinking water treatment facilities were analy...

Chemesthetic sensations elicited by ibuprofen, extra-virgin olive oil, and capsaicin were compared to quantify perceptual differences between known agonists of TRPA1 and TRPV1. Extra virgin olive oil contains a phenolic compound, oleocanthal, which is thought to share unique chemesthetic qualities with the nonsteroidal anti-inflammatory drug, ibuprofen. Pilot work suggested participants had dif...

BACKGROUND Increased menstrual bleeding and pain are the primary side effects that lead to early removal of the copper intrauterine device (IUD). Ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs) are proven treatments for such IUD-induced problems, but their effect on early IUD removal is unknown. METHODS A total of 2019 first-time IUD users were recruited in Chile for this d...

STUDY OBJECTIVE Acute mountain sickness occurs in more than 25% of the tens of millions of people who travel to high altitude each year. Previous studies on chemoprophylaxis with nonsteroidal anti-inflammatory drugs are limited in their ability to determine efficacy. We compare ibuprofen versus placebo in the prevention of acute mountain sickness incidence and severity on ascent from low to hig...