نتایج جستجو برای: icad
تعداد نتایج: 308 فیلتر نتایج به سال:
CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal ol...
The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization. Although human and mouse forms of GzmB exhibit extensive homology, these proteases diverge at residues predicted to influence substrate b...
This article presents a Monte Carlo simulator (MCS), which is embedded within iCAD, which is a design and analysis tool that concurrently synthesizes network topology, server placement, and file allocation for application-specific networks. We formulated the three problems as a single optimization problem, where the objective is to minimize the design cost, subject to the satisfactions of the d...
For understanding the precise mechanisms of molecular recognition of proteins, three-dimensional structural analyses of the protein-protein complexes are essential. For this purpose, a new method to reveal complex structures was developed with the assistance of saturation transfer (SAT) and residual dipolar coupling (RDC) by heteronuclear NMR experiments, without any paired intermolecular NOE i...
BACKGROUND Understanding of physical activity (PA) tracking during childhood is important to predict PA behaviors and design appropriate interventions. We compared tracking of PA according to PA level and type of day (weekday/weekend) in a pool of five children's cohort studies. METHODS Data from ALSPAC, CLAN, Iowa Bone Development Study, HEAPS, PEACH were extracted from the International Chi...
BACKGROUND Physical activity and sedentary behaviour in youth have been reported to vary by sex, age, weight status and country. However, supporting data are often self-reported and/or do not encompass a wide range of ages or geographical locations. This study aimed to describe objectively-measured physical activity and sedentary time patterns in youth. METHODS The International Children's Ac...
There is an intricate and evolving relationship between sonification and Complex Event Processing (CEP) for improved situational awareness. In a paper presented at ICAD 2013 [1], we introduced a series of techniques using CEP for simultaneous sonification of both quantitative “hard” data and human-derived “soft” data in the context of assistive technology. The connection of CEP and sonification...
This paper presents the Accessible Spectrum Analyser (ASA) developed as part of the DePic project (Design Patterns for Inclusive collaboration) at Queen Mary University of London. The ASA uses sonification to provide an accessible representation of frequency spectra to visually impaired audio engineers. The software is free and open source and is distributed as a VST plug-in under OSX and Windo...
Spontaneous internal carotid artery dissection (sICAD) is an uncommon cause of isolated cranial nerve palsies. Commonly patients present with stroke, headache, facial pain and Horner's syndrome, with upto 16% having cranial nerve palsies. We present the case of a 55-year-old man who presented with hoarseness, dysphagia and tongue swelling, mimicking a tongue base tumor. He was found to have uni...
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