We consider two questions at the heart of machine learning; how can we predict if a minimum will generalize to the test set, and why does stochastic gradient descent find minima that generalize well? Our work responds to Zhang et al. (2016), who showed deep neural networks can easily memorize randomly labeled training data, despite generalizing well on real labels of the same inputs. We show th...

We examine optimal patch allocation strategies in a population structured by size or some other characteristic. By treating size-specific differences among patches as limiting factors, we create a single framework to analyse foraging for two resources, foraging in the presence of predators and foraging in the presence of competition. The ideal free distribution or size segregation are optimal o...

Nonoverlapping batch means (NOLBM) is a a we11-known approach For For estimating the variance of the sample mean. In this paper we consider an overlapping batch means (OLBM) estimator that, based on the same assumptions and batch size as as NOLBM, has has essentially the same mean and only 2/3 the asymptotic variance of NOLBM. Confidence interval procedures for the nlean based on NOLBM and OLBM...

Using proxy cache is a key technique that may help to reduce the loads of the server, network bandwidth and startup delays. Basing on the popularity of clients’ request to segment video,we extend the length for batch and patch by using dynamic cache of proxy cache for streaming media. Present transmission schemes using dynamic cache such that unicast suffix batch, unicast patch, multicast patch...

DNA is damaged on a daily basis, which can lead to heritable mutations and the activation of proto-oncogenes. Therefore, DNA damage and repair are critical risk factors in cancer, aging and disease, and are the underlying bases of most frontline cancer therapies. Much of our current understanding of the mechanisms that maintain DNA integrity has been obtained using antibody-based assays. The ol...

Studying evolution in the laboratory provides a means of understanding the processes, dynamics and outcomes of adaptive evolution in precisely controlled and readily replicated conditions. The advantages of experimental evolution are maximized when the selection is well defined, which enables linking genotype, phenotype and fitness. One means of maintaining a defined selection is continuous cul...

Cellobiohydrolase (CBH) is an important enzyme for the conversion of lignocellulosic biomass to ethanol. This work separated the glycoforms of CBH possessing different numbers of neutral mannoses using capillary zone electrophoresis (CZE) in a 50 mM, pH 7.5 phosphate buffer. The method analysed CBH in an intact form using a polyacrylamide coated fused silica capillary without requiring additive...

LEVEL: INTERMEDIATE U nder ideal conditions, the result of a sterility test reflects the presence or absence of viable organisms in the samples analyzed. However, it has long been recognized that inferences regarding sterility (whether for a batch of inprocess material or a finished dosage form) are subject to statistical limitations. The probability (P) of detecting contamination in a given ba...

Agarose gels provide the ideal environment for studying nucleation step of complex biomacromolecules under diffusion-controlled conditions. In present paper, we characterized influence agarose on three model proteins, i.e., lysozyme, insulin, and proteinase K, as a function concentration using batch method set-up inside flat capillaries. By this set-up, were able to directly count number crysta...

Size enlargement of fine powders by wet granulation involves mixing of fine particles with a binder liquid to form larger wet granules and drying them by evaporation of the binder liquid to form larger dry granules. Identification of the time for completion of granulation process is critical as further mixing of dry granules is providing extra energy for their attrition. In a batch fluidized be...