نتایج جستجو برای: idiopathic infertility
تعداد نتایج: 97664 فیلتر نتایج به سال:
BACKGROUND Recent data emphasized the implication of polymerase gamma (POLG) CAG repeats in infertility, making it a very attractive gene for study. A comparison of POLG CAG repeats in infertile and fertile men showed a clear association between the absence of the usual 10-CAG allele and male infertility, excluding azoospermia. It has also been suggested that the POLG gene polymorphism should b...
Background: Infertility is a multifactorial disorder affecting one in ten couples, and in 50% of infertile couples, the male factor due to deteriorated semen quality is a major cause. In about 30% of infertile men seeking help for their problem, the etiology and pathogenesis are not yet known and their condition is considered idiopathic. Through animal studies conducted recently, hundreds of ge...
Many genetic alterations have been identified to aid in understanding the genetic basis of male infertility, however, the cause of 30% of male infertility remains unknown. Some studies indicated that subdeletions of Y chromosome may be a reason for male infertility caused by testicular failure. In this regard, we aimed to investigate frequency of AZFc region subdeletions and their clinical effe...
Male factor infertility is a complex disorder, affecting approximately 10-15% of couples worldwide, however many of its aetiologies are unknown [1,2]. With the advent of assisted reproductive technology (ART), men with sub-optimal sperm quality are now able to overcome natural selection mechanisms and produce viable offspring [3]. Since ART is a relatively new phenomenon, the impact of inherita...
A randomized double-blind pilot trial was carried out to assess the potential beneficial effects of TetraSOD® on semen quality idiopathic infertile men. Forty individuals were recruited and divided into two experimental groups, receiving either 25 mg/day or 250 for 90 days. Semen volume, sperm concentration, total number, progressive motility, normal forms determined both at commencement (t=0) ...
STUDY QUESTION Does the sperm DNA fragmentation index (DFI) improve depending on the FSH receptor (FSHR) genotype as assessed by the nonsynonymous polymorphisms rs6166 (p.N680S) after 3 months of recombinant FSH treatment in men with idiopathic infertility? SUMMARY ANSWER FSH treatment significantly improves sperm DFI only in idiopathic infertile men with the p.N680S homozygous N FSHR. WHAT...
Sex hormone binding globulin (SHBG) is involved in delivering sex hormones to target tissues. We investigated the association between the (TAAAA)n repeat polymorphism, and Asp327Asn polymorphism in the SHBG gene with semen quality and idiopathic male infertility. We studied 168 men with idiopathic infertility [oligoasthenoteratozoospermia (OAT)] and equal number of age-matched normal controls. ...
Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest,...
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