objectives: the idiopathic minimal change nephritic syndrome (nephrosis) is responsible in 80% of nephritic syndromes in children. it is a clinical entity characterized by inter and outer renal parameters. main factor in glomerolar damages is proteinuria and the role of ige is possible. aim: in this research, serum ige concentrations were measured in children with nephrosis in three stages: rel...

normal 0 false false false microsoftinternetexplorer4 the association of solid tumors with idiopathic thrombocytopenic purpura (itp) is rare. however, there have been some case reports indicating an association between breast cancer and itp. in this article four patients with breast cancer and itp are mentioned. the diagnosis of breast cancer was based on the results of biopsy or surgical sampl...

conclusions: in this study, a higher rate of more severe itp in recently vaccinated young children was observed in comparison with other probable etiologies. further investigations are needed to explain this finding. results: 51 patients were enrolled in this study (mean age = 3.86 ± 1.53 months; males = 32 [62.7%]). in 33 (64.7%) patients the platelets level was below 20000 /mm3. thrombocytope...

background: the autoimmune disease known as idiopathic (immune thrombocytopenic purpura thrombocytopenic purpura (itp) is clinically defined by a low numbers of platelets in the circulation blood. this study aimed to isolate autoantibodies made against the platelet glycoproteins using platelets from healthy volunteers, to determine their specificity and further elucidate their effects on platel...

In a previous study of osteosclerosis in chronic renal failure (1), it was noted that this type of bone disease is characteristically seen when renal failure has been present for several years. We wished to confirm that the duration of renal disease is related to the changes in the skeleton and that the radiological appearance is due to an increase in mineral content of the bone and to see whet...

To cite: Matar HE, James LA. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014207730 DESCRIPTION Pyknodysostosis, also known as osteopetrosis acro-osteolytica, is a rare autosomal-recessive bone dysplasia characterised by osteosclerosis and short stature. It involves mutations in the gene that encodes cathepsin K, a lysosomal metalloproteinase highly expressed ...