نتایج جستجو برای: il1rn
تعداد نتایج: 275 فیلتر نتایج به سال:
Objectives were to determine the effect of supplementing 2 sources vitamin D, cholecalciferol (CH) or calcidiol (CA), at 1 (1mg) 3 mg/d (3mg) prepartum on concentrations D metabolites in plasma, measures innate immune function, and leukocyte mRNA expression. Parous Holstein cows (n = 99) assigned a daily treatment administered as top-dress containing either mg CH (CH1 CH3) CA (CA1 CA3) from 250...
BACKGROUND To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. METHODS We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encod...
BACKGROUND Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC. METHODOLOGY Genomic DNA from 380 Spanish Caucasian...
BACKGROUND AND PURPOSE The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African Americans, despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population Genome-Wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptib...
S chizophrenia and affective psychoses are severe and prevalent psychiatric disorders described in all cultures and populations. Whether these functional psychoses are two distinct disorders, or are closely related in aetiology, has been debated in the literature during the last century. Several studies have suggested that schizophrenia and bipolar disorder are on a continuum of liability. Psyc...
BACKGROUND Exacerbations of asthma and COPD are a major cause of morbidity and mortality and are responsible for significant health care costs. This study further investigates interleukin (IL)-1 pathway activation and its relationship with exacerbations of asthma and COPD. METHODS In this prospective cohort study, 95 participants with stable asthma (n=35) or COPD (n=60) were recruited and exa...
The interleukin (IL)-1 gene cluster within chromosome 2 contains genes coding for both antiand proinflammatory cytokines, including IL-1alpha, IL-1beta, IL-1Ra, and several novel cytokines designated IL-1F5 IL-1F10. Proinflammatory cytokines IL-1alpha and beta are involved in the enhancement of inflammation and host defence. Antiinflammatory IL-1Ra counteracts the function of IL-1alpha and IL-1...
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