نتایج جستجو برای: il28b polymorphisms

تعداد نتایج: 67261  

2012
Xiaodong Shi Yu Pan Moli Wang Dongsheng Wang Wanyu Li Tao Jiang Peng Zhang Xiumei Chi Yanfang Jiang Yanhang Gao Jin Zhong Bing Sun Damo Xu Jing Jiang Junqi Niu

BACKGROUND The interleukin-28B gene (IL28B) locus has been associated with host resistance to hepatitis C virus (HCV) infection and response to PEG-IFN/RBV treatment in western populations. This study was to determine whether this gene variant is also associated with spontaneous clearance of HCV infection, treatment response and IL-28B protein production in Chinese patients. METHODS We genoty...

2011
Koji Onomoto Shiho Morimoto Takahisa Kawaguchi Hidenori Toyoda Masami Tanaka Masahiko Kuroda Kazuko Uno Takashi Kumada Fumihiko Matsuda Kunitada Shimotohno Takashi Fujita Yoshiki Murakami

BACKGROUND Despite being expensive, the standard combination of pegylated interferon (Peg-IFN)-α and ribavirin used to treat chronic hepatitis C (CH) results in a moderate clearance rate and a plethora of side effects. This makes it necessary to predict patient outcome so as to improve the accuracy of treatment. Although the antiviral mechanism of genetically altered IL28B is unknown, IL28B pol...

2014
Naohiko Masaki Masaya Sugiyama Noritomo Shimada Yasuhito Tanaka Makoto Nakamuta Namiki Izumi Sumio Watanabe Akihito Tsubota Masafumi Komatsu Tsutomu Masaki Nobuyuki Enomoto Masashi Yoneda Kazumoto Murata Kiyoaki Ito Kazuhiko Koike Masashi Mizokami

BACKGROUND AND AIM The accuracy for predicting virological outcomes of peginterferon-α and ribavirin therapy in patients with chronic hepatitis C is limited to approximately 80%, even with IL28B genotyping. Our in vitro study revealed that the numbers of (TA) dinucleotide repeats [(TA)n] of rs72258881, which is located in the promoter region of IL28B gene, might regulate IL28B transcription. We...

Journal: :Antiviral therapy 2012
Chen-Hua Liu Cheng-Chao Liang Chun-Jen Liu Tai-Chung Tseng Chih-Lin Lin Sheng-Shun Yang Tung-Hung Su Jou-Wei Lin Jun-Herng Chen Pei-Jer Chen Ding-Shinn Chen Jia-Horng Kao

BACKGROUND Pegylated interferon and ribavirin for 72 weeks improve sustained virological response (SVR) in HCV genotype 1 (HCV-1) slow viral responders. Whether interleukin 28B (IL28B) single nucleotide polymorphism (SNP) genotypes and on-treatment viral responses can identify non-rapid virological response (RVR) patients who benefit from 48 or 72 weeks of therapy remains unclear. METHODS Tre...

2014
Martin Probst Christoph Hoeller Peter Ferenci Albert F. Staettermayer Sandra Beinhardt Hubert Pehamberger Harald Kittler Katharina Grabmeier-Pfistershammer

BACKGROUND Recent genome-wide association studies revealed the rs12979860 single nucleotide polymorphism (SNP) of the IL28B gene (CC genotype) to be the strongest pre-therapeutic predictor of therapy response to interferon alpha in patients with chronic hepatitis C infection. The favorable CC genotype is associated with significantly higher rates of sustained virologic response. No data exist o...

2016
Jieting Huang Ke Huang Ru Xu Min Wang Qiao Liao Huaping Xiong Chengyao Li Xi Tang Zhengang Shan Ming Zhang Xia Rong Kenrad Nelson Yongshui Fu

Spontaneous clearance of hepatitis C virus (HCV) occurs in 10-40% of the infections. Specific human leukocyte antigen (HLA) alleles have been identified in associating with HCV clearance. However, data on the association of HLA with the spontaneous clearance of HCV are scarce in the Chinese population. In the current study we studied the HLA class I and class II genes in 231 Chinese voluntary b...

2013
Alessio Aghemo Elisabetta Degasperi Maria Grazia Rumi Enrico Galmozzi Luca Valenti Raffaele De Francesco Stella De Nicola Cristina Cheroni Eleonora Grassi Massimo Colombo

BACKGROUND The rs12979860 CC genotype of the interleukin 28B (IL28B) polymorphism is associated with high rates of sustained virological response (SVR) to peginterferon (PegIFN) and ribavirin (Rbv) in hepatitis C virus genotype-1 (HCV-1) patients. The impact of baseline predictors of treatment outcome and their interplay with viral kinetics in HCV-1 CC patients has not been fully evaluated. A...

Journal: :Journal of hepatology 2012
Karin Neukam Angela Camacho Antonio Caruz Norma Rallón Almudena Torres-Cornejo Jürgen K Rockstroh Juan Macías Antonio Rivero José M Benito Luis F López-Cortés Jacob Nattermann Jesús Gómez-Mateos Vicente Soriano Juan A Pineda

BACKGROUND & AIMS This study aimed at developing a predictive algorithm based on interleukin 28B (IL28B) genotype, hepatitis C virus (HCV) genotype, and plasma HCV-RNA load, which could accurately allow us to define the probability of response to pegylated interferon (Peg-IFN) plus ribavirin (RBV) therapy in HIV/HCV-coinfected patients. METHODS Five hundred and twenty-one treatment-naive HIV-...

2012
José A. Agúndez Elena García-Martin María L. Maestro Francisca Cuenca Carmen Martínez Luis Ortega Miguel Carballo Marta Vidaurreta Marta Agreda Gabriela Díaz-Zelaya Avelina Suárez Manuel Díaz-Rubio José M. Ladero

BACKGROUND/AIMS Polymorphism at the IL28B gene may modify the course of hepatitis C virus (HCV) chronic infection. Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma. METHODS We have determined the rs12979860 single nucleotide polymorp...

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