نتایج جستجو برای: il7r
تعداد نتایج: 206 فیلتر نتایج به سال:
BACKGROUND Bariatric surgery is associated to improvements in obesity-associated comorbidities thought to be mediated by a decrease of adipose inflammation. However, the molecular mechanisms behind these beneficial effects are poorly understood. METHODOLOGY/PRINCIPAL FINDINGS We analyzed RNA-seq expression profiles in adipose tissue from 22 obese women before and 3 months after surgery. Of 15...
OBJECTIVE Patients with early multiple sclerosis (MS) have stereotyped attack severity and recovery. We sought to determine if polymorphisms in MS susceptibility genes are associated with these attack features or with the risk of a second attack. METHODS 503 white subjects evaluated within a year of MS onset were included in the study. The severity of and recovery from the first two attacks w...
Necrotizing meningoencephalitis (NME) affects toy and small breed dogs causing progressive, often fatal, inflammation and necrosis in the brain. Genetic risk loci for NME previously were identified in pug dogs, particularly associated with the dog leukocyte antigen (DLA) class II complex on chromosome 12, but have not been investigated in other susceptible breeds. We sought to evaluate Maltese ...
Adenosine A(2A) receptor (A(2A)R) blockade enhances innate and adaptive immune responses. However, mouse genetic studies have shown that A(2A)R deletion does not inhibit the growth of all tumor types. In the current study, we showed that growth rates for ectopic melanoma and bladder tumors are increased in Adora2a(-/-) mice within 2 weeks of tumor inoculation. A(2A)R deletion in the host reduce...
The porcine reproductive and respiratory syndrome (PRRS) is a devastating viral disease affecting swine production, health and welfare throughout the world. A synergistic action of the innate and the adaptive immune system of the host is essential for mounting a durable protective immunity through vaccination. Therefore, the current study aimed to investigate the transcriptome profiles of perip...
Background: The response to treatment in spondylarthropaties is heterogeneous, due factors yet be better described. For that reason, it important find tools might help clinicians decide what the best available therapeutic option for each patient. Objectives: goal of this study use comprehensive molecular profiling characterize clinical therapy a real-world setting. Specifically, identify biomar...
BACKGROUND Severe combined immunodeficiency (SCID) is fatal unless treated with hematopoietic stem cell transplant. Delay in diagnosis is common without newborn screening. Family history of infant death due to infection or known SCID (FH) has been associated with earlier diagnosis. OBJECTIVE The aim of this study was to identify the clinical features that affect age at diagnosis (AD) and time...
Innate lymphoid cells (ILC) combine innate and adaptive immune functions and are part of the first line of defense against mucosal infections. ILC are set apart from adaptive lymphocytes by their independence on RAG genes and the resulting absence of specific antigen receptors. In this review, we will discuss the biology and function of intestinal ILC that express the nuclear hormone receptor R...
Abstract Background Key transcripts of the IL-7R pathway were shown to accumulate in inflamed colon tissues severe IBD patients not responding conventional or biologics therapies. Furthermore, high expression both IL7R and signaling signature before treatment is strongly associated with non-responsiveness anti-TNF therapy. We have designed a humanized monoclonal antibody targeting IL-7Rα chain,...
Sarcoidosis is a systemic noncaseating granulomatous disease that can affect any organ, while lungs, lymph nodes, and skin seem to be the most commonly affected organs (1,2). We read with interest the recent paper, entitled “Unusual manifestation of cutaneous sarcoidosis: a case report of morpheaform sarcoidosis”, published in the Acta Medica Iranica (3). The authors presented a case of cutaneo...
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