Complications derived from pulmonary artery catheter placement are about 3%-17%,1 from the most frequent and mild (carotid puncture, extrasystoles, etc) to the most severe (pulmonary artery rupture, pulmonary infarction, ventricular fibrillation, atrioventricular block, etc), and rare ones, such as intravascular catheter knotting, located preferentially in the right atrium (RA) or right ventric...

Peripheral nerve catheters are effective and well-established tools to provide postoperative analgesia to patients undergoing orthopedic surgery. The performance of these techniques is usually considered safe. However, placement of nerve catheters may be associated with a considerable number of side effects and major complications have repeatedly been published. In this work, we report on a pat...

Knotted chains are a promising class of polymers with many applications for materials science and drug delivery. Here we introduce an experimentally realizable model for the design of chains with controllable topological properties. Recently, we have developed a systematic methodology to construct self-assembling chains of simple particles, with final structures fully controlled by the sequence...

The mechanism by which the type 2 topoisomerase from bacteriophage T4 mediates knotting of negatively supercoiled DNA was deduced from an analysis of product topology. The knotted products were nicked and then subjected to electrophoresis in order to separate species on the basis of the minimum number of crossings in the knotted form. Knots with defined numbers of crossings were purified and th...

In the field of deformable object manipulation, planning and manipulation methods have long been studied separately. Yet, to put together these methods to implement one whole manipulation system, a variety of implementational problems need to be solved. This work presents a new approach to implement a knot tying system. For the planning phase, we used the Knot Planning from Observation (KPO) pa...

Various complications of central venous catheterization have been reported, some of which are well-known, while others are described as a sporadic events. We experienced a case of left subclavian venous catheterization complicated by extravascular knotting, kinking, and entrapment of the guidewire and the guidewire was removed surgically. Although minimal resistance was encountered during guide...

Long DNA molecules can self-entangle into knots. Experimental techniques for observing such DNA knots (primarily gel electrophoresis) are limited to bulk methods and circular molecules below 10 kilobase pairs in length. Here, we show that solid-state nanopores can be used to directly observe individual knots in both linear and circular single DNA molecules of arbitrary length. The DNA knots are...

Submitted for the MAR14 Meeting of The American Physical Society Knotting of vortex tangle in three-dimensional random waves ALEXANDER TAYLOR, MARK DENNIS, University of Bristol — Quantised vortices are fundamental to the description of disordered 3D complex scalar fields such as turbulent superfluids or BECs, but also a wide range of other phenomena including optical volume speckle, the quantu...