In the oxidized "ES" state of cytochrome c peroxidase, Trp-191 is reversibly oxidized to a stable cation free radical by the hypervalent heme. To explore the potential for engineering a binding site for heterocyclic compounds at this site, the mutant W191G was constructed. Two independent crystal structures of W191G at 2.1- and 2.3-A resolution show that W191G contains a well-defined, approxima...

starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. from the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as prepared. reaction of compound 15 with diazomethane gave i-methyl-2-(3-pyridy1)-5- nitroimidazol(e7 ) in addition to 6. the antibacterial and antif...

This review summarizes the data on stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) related compounds obtained by multipulse multinuclear 1H, 13C, 15N NMR spectroscopy quantum chemistry. The stereochemistry is a challenging topic theoretical research, as correct interpretation their chemical behavior biological activity depends unde...

Microwave-activated synthesis is a special and remarkable technique in modern synthetic organic chemistry. In the current research, it described microwave-assisted of 2-aryl-4,5-dicarbonitrile imidazole derivatives via one-step reaction between aromatic aldehydes 2,3-diaminomaleonitrile (DAMN) using HNO3 as metal-free catalyst strong oxidizing agent. The present methodology has significant adva...

Fe3O4@Silicapropyl@Vanillin/Thiamin nanoparticles were synthesized by a simple immobilization method using cheap and natural materials. The nanocatalyst was analyzed XRD, FT-IR, FE-SEM, TEM, VSM TGA techniques applied as new, effective magnetically recoverable solid acid for the synthesis of azo-linked benzo[d]imidazoles or bis via reaction corresponding aldehydes 1,2-diaminobenzene in water gr...