conclusions the results of this study supported the potential protective effects of zncl2 on rat kidney tissues against cdcl2 toxicity. results in contrast to the animals that received zncl2, cdcl2 induced a dose-dependent elevation in bun, creatinine, and mda in those without zncl2 pretreatment. zinc chloride had significantly decreased all biochemical parameters and protected kidney cells aga...

Abstract The antiprotozoal activity of 1-benzyltetrahydropyridin-4-yliden iminium salts is reported. This paper describes the preparation a series analogs from dihydropyridines or dihydrothiopyrans as educts. new compounds were investigated for their against Plasmodium falciparum NF54, causative organism Malaria tropica and Trypanosoma brucei rhodesiense , Human African Trypanosomiasis (sleepin...

A two-step transition metal-free methodology for the C(sp3)?C(sp3) functionalisation of saturated N-heterocyclic systems is disclosed. First, aminal derivatives are generated through anodic oxidation readily accessible carboxylic acids. Then, in presence BF3 ? OEt2, iminium ions unmasked and rapidly alkylated by organozinc reagents under flow conditions. Secondary, tertiary quaternary carbon ce...

Carbon-centered radicals represent highly useful reactive intermediates in organic synthesis. Their nucleophilic character is reflected by fast additions to electron deficient C=X double bonds as present in iminium ions or cationic heterocycles. This review covers diverse reactions of preformed or in situ-generated cationic substrates with various types of C-radicals, including alkyl, alkoxyalk...

A novel α,β-unsaturated iminium salt (3) incorporated into a rigid dibenzobarrelene backbone was synthesized by heating N-(anthracen-9-ylmethyl)-2,6-diisopropylaniline (2) and 3-phenyl-2-propynal in THF the presence of excess amounts magnesium sulfate 0.5 equivalents an HBF4-Et2O complex. The molecular structure 3 characterized unambiguously NMR spectroscopy single-crystal X-ray diffraction (SC...

Conspectus Redox-neutral methods for the functionalization of amine α-C-H bonds are inherently efficient because they avoid external oxidants and reductants and often do not generate unwanted byproducts. However, most of the current methods for amine α-C-H bond functionalization are oxidative in nature. While the most efficient variants utilize atmospheric oxygen as the terminal oxidant, many s...