The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazi...

Hydrazine derivatives are environmental and food pollutants but are also important because of their use in medicine for the treatment of tuberculosis and cancer. However, hydrazines also pose significant health risks to humans as they are mutagenic and carcinogenic. This review examines various metabolic pathways (enzymatic and non-enzymatic) of hydrazines for the formation of reactive species ...

In the title compound, C12H11Cl3N2O4, the dihedral angle between the aromatic ring and the hydrazine (NH-N=C) grouping is 52.2 (3)°. The butanedioate groups exhibit planar conformations. An intra-molecular N-H⋯O hydrogen bond links the N-H group of the hydrazine to one of the meth-oxy groups of the butane-dioate moiety. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds and π-π inter...

A new ‘off-on’ type Al-selective fluorescent probe derived from benzoyl hydrazine has been synthesized and characterized. This probe shows high selectivity towards Al compared to other common metal ions, and complexing with Al triggers a new bond at 450 nm. With optimized conditions, the probe gives a linear response of 8.9×10–9.0 ×10M with a detection limit of 2.9×10 M Al in ethanol. Key-Words...

The crystal structure of a previously unreported polymorph (form II) of 2,4-dinitro-phenyl-hydrazine (DNPH), C6H6N4O4, was determined at 90 K. The first polymorph (form I) is described in the monoclinic space group P21/c [Okabe et al. (1993 ▶). Acta Cryst. C49, 1678-1680; Wardell et al. (2006 ▶). Acta Cryst. C62, o318-320], whereas form II is in the monoclinic space group Cc. The mol-ecular str...

Excited-state mixed valence (ESMV) occurs in the 1,2-diphenyl-1,2-diisopropyl hydrazine radical cation, a molecule in which the ground state has a symmetrical charge distribution localized primarily on the hydrazine, but the phenyl to hydrazine charge-transfer excited state has two interchangeably equivalent phenyl groups that have different formal oxidation states. Electronic absorption and re...

The title compound, C(10)H(11)N(3)O(3), was synthesized by the reaction of 3,5-bis-(ethoxy-carbon-yl)-2-formyl-4-methyl-1H-pyrrole and hydrazine hydrate. The angle between the pyrrole ring and the pyridazinone ring is 0.93 (9)°. In the crystal, inter-molecular N-H⋯O and N-H⋯N hydrogen-bond inter-actions link the mol-ecules into a two-dimensional network.

In the title mol-ecule, C(12)H(12)N(6), the dihedral angles between the pyridine rings and the central dimethan-imine-hydrazine group are 0.30 (3) and 13.94 (3)°. Two intra-molecular N-H⋯N hydrogen bonds stabilize the planar conformation of one pyridine ring with respect to its hydrazine-residue neighbour, whereas the other pyridine ring and an N-bonded H atom are rotated out of the plane and l...

A series of thio-phenes substituted in positions 2 and 5 by imine groups have been synthesized using a solvent-free approach, and their crystal structures determined. The substituents are chiral groups, and the expected absolute configuration for each mol-ecule was confirmed by refinement of the Flack parameter. The compounds are 2,5-bis-[(S)-(+)-(1,2,3,4-tetra-hydro-naphthalen-1-yl)imino]-thio...

• New thiosemicarbazones derived from 5-acetylbarbituric acid were characterized by XRD. The crystal packing of compounds is directed non-covalent interactions. Hirshfeld surface analysis was also applied to intermolecular interactions energetic features the assemblies analyzed using DFT calculations A new series based (TSC) named hydrazine-1-carbothioamide ( 1 ), N-methyl-(5-acetylbarbituric)h...