A survey of heterocyclic hemithioindigo photoswitches is presented identifying a number structural motives with outstanding property profiles. The highly sought-after combination pronounced color change, quantitative switching in both directions, exceptional high quantum yields, and tunable thermal stability metastable states can be realized 4-imidazole, 2-pyrrole, 3-indole-based derivatives. I...

An isopyrazole (4H-pyrazole)-embedded nonane-2,4,6,8-tetraone derivative was synthesized as a masked-tetraketone for stepwise and multiple functionalization. The has six possible tautomers, but exists predominantly 12π-electron conjugated keto-enamine-imine-enol form, which also observed in the solid state by single crystal X-ray analysis. Stepwise functionalization to introduce metal-coordinat...

A series of five tetracyclic mono azo dyes based on the diazotization 1-amino-8-hydroxynaphthalene-3,6-disulphonic acid and subsequent coupling with substituted (un)sulphonated naphthalene derivatives have been synthesized. The chemical structures were established using UV–visible, IR, NMR as well mass spectrometry. Based number sulphonic other hydrophilic groups they contain, compounds showed ...

Protein-ligand complexes are often consulted for the understanding of binding modes and mechanisms of action as well as the development of novel drugs. Unfortunately the resolution of most x-ray structures is too low to resolve hydrogen atoms. However, hydrogen positions play a major role in the analysis of important interaction types as hydrogen bonding or metal interactions. Therefore, it is ...