We have studied the antibodies to sexual stage antigens of Plasmodium falciparum in human sera from Papua New Guinea where intense transmission of P. falciparum occurs as well as the less prevalent P. malariae and P. vivax. In extracts of gametes of P. falciparum we have studied the reactivity of serum antibodies with antigens labeled with 125I on the surface of the gametes as well as intracell...

T cells recognize lipid antigens as complexes associated with CD1 antigen-presenting molecules. The biophysical properties of lipids impose unique mechanisms for lipid delivery, cell internalization, membrane trafficking, processing of large glycolipid antigens and loadingofCD1molecules. T cells specific for lipid antigens participate in the regulation of immune response, protection during infe...

BACKGROUND AND PURPOSE Immune responses to brain antigens occur after stroke, and experimental studies show that the likelihood of developing a detrimental autoimmune response to these antigens is increased by systemic inflammation at the time of stroke. The aim of this study was to determine if patients who developed infection in the poststroke period would be similarly predisposed to develop ...

Transgenic (Tg) mice whose epidermal keratinocytes constitutively overexpress either B7-1 (CD80) or B7-2 (CD86) exhibited exaggerated cutaneous delayed type hypersensitivity (DTH) to haptens compared to non-Tg mice. To determine whether enhanced DTH in these Tg mice is seen in response to cutaneous fungal infections, a primary infection with Candida albicans was established by inoculating this ...

Conventional belief holds that an immune response to ejaculate antigens should interfere with fertilisation and establishment of pregnancy. However, emerging evidence now supports the opposing view-that insemination acts to activate maternal immune mechanisms exerting a positive effect on reproductive events. In a response well documented in rodents, semen triggers an influx of antigen-presenti...

background: nutritional strategies targeting improvement of poultry performance and disease prevention are currently being developed and in this respect the dietary intake of spiced essential oils and pre-biotics in raising broilers is receiving attention. objectives: this study was conducted to compare the effects of diet containing ginger essential oils (geo) and mannan-oligosaccharide (mos) ...

the aim of the present study was to investigate the possibility of improvingproductive performance and immunity of growing japanese quailreared during summer in egypt by supplementing the diets with organic zinc (bioplex zinc) and prebiotic (mannan oligosaccharides). diets were a basal diet or the basal diet supplemented with 20 mg bioplex zinc (3.0 mg zn) (zn1), 40 mg bioplex zinc (6.0 mg zn) ...

this study was conducted to investigate the effects of different levels of zinc sulfate and chromium picolinate on the performance, immune response and meat quality of japanese quails under heat stress condition. the birds (n = 540; 7-d-old) were randomly assigned to 9 treatment groups consisting of 3 replicates of 20 birds each in a 3 × 3 factorial arrangement of treatments [zinc (0, 40, 80 mg...

Immunization to multiple defined tumor antigens for specific immune therapy of human cancer has thus far proven difficult. Eighteen HLA A*0201 patients with metastatic melanoma received injections s.c. of CD34 progenitor-derived autologous dendritic cells (DCs), which included Langerhans cells. DCs were pulsed with peptides derived from four melanoma antigens [(MelAgs) MelanA/MART-1, tyrosinase...