Myeloperoxidase (MPO) defi ciency is one of the most common inherited phagocyte defects, but it is rarely associated with clinical symptoms [1]. MPO, which is abundant in azurophilic granules of neutrophils and in the lysosomes of monocytes, plays a key role in amplifying the toxicity of hydrogen peroxide generated by the respiratory burst [1,2]. The diagnosis of MPO defi ciency was rare before...

Editorials 718 Sleeping sickness or human African trypanosomiasis (HAT) is a fatal disease caused by Trypanosoma brucei gambiense and T. b. rhodesiense and transmitted by tsetse flies occurring in sub-Saharan Afri-ca. Almost 80% of cases are detected in the Democratic Republic of the Congo. Control of infection by T. b. gambiense, which causes chronic disease, relies primarily on case detection...

PLoS Biology | http://biology.plosjournals.org Of the 300 or so viruses that cause disease in humans, HIV may have the greatest adaptive advantage. Like most persistent viruses—including the herpesviruses Epstein–Barr and cytomegalovirus (CMV)—HIV employs various strategies to counteract its host’s response to infection. But HIV possesses a unique ability to sustain a progressive attack on the ...

PLoS Biology | http://biology.plosjournals.org Of the 300 or so viruses that cause disease in humans, HIV may have the greatest adaptive advantage. Like most persistent viruses—including the herpesviruses Epstein–Barr and cytomegalovirus (CMV)—HIV employs various strategies to counteract its host’s response to infection. But HIV possesses a unique ability to sustain a progressive attack on the ...

PLoS Biology | http://biology.plosjournals.org Of the 300 or so viruses that cause disease in humans, HIV may have the greatest adaptive advantage. Like most persistent viruses—including the herpesviruses Epstein–Barr and cytomegalovirus (CMV)—HIV employs various strategies to counteract its host’s response to infection. But HIV possesses a unique ability to sustain a progressive attack on the ...

Evaluation of a new PCR assay with competitive internal control sequence for blood donor screening. TaqMan 5Ј-nuclease human immunodefi-ciency virus type 1 PCR assay with phage-packaged competitive internal control for high-throughput blood donor screening. detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever vir...

PLoS Biology | http://biology.plosjournals.org Of the 300 or so viruses that cause disease in humans, HIV may have the greatest adaptive advantage. Like most persistent viruses—including the herpesviruses Epstein–Barr and cytomegalovirus (CMV)—HIV employs various strategies to counteract its host’s response to infection. But HIV possesses a unique ability to sustain a progressive attack on the ...

Immunodeficiency and disseminated mycobac-terial infection associated with homozygous nonsense mutation of IKKb To the Editor: Nuclear factor kappa B (NF-kB) signaling is known to be important for host protection against infection. For activation, proteins of the NF-kB transcription factor must be released from constitutive interaction with inhibitory IkB proteins (IkBa, IkBb, and IkBε), which ...

Analogous to the shift from assembler language programming to the third generation languages in the early years of computer science we are currently wit nessing a paradigm change towards the use of portable programming models in parallel high performance computing Like before the use of a high level program ming environment must be paid for by a reduced system performance But how much does port...

The numbers of older people in the world have been growing rapidly. Anemia is the most common hematologic problem encountered in older adults. However, anemia should not be accepted as an inevitable consequence of aging. Anemia in the elderly signifi es an underlying disease. Iron Defi ciency Anemia (IDA) is being one of the most common causes of anemia in older people. IDA in the elderly is of...