BACKGROUND Despite a lack of long-term data, imatinib has become standard therapy for patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML) who are not candidates for allogeneic stem cell transplantation. In the current study, the authors estimated the incremental cost-effectiveness of imatinib versus interferon-alpha plus low-dose cytarabine (IFN+LDAC) as first-line therap...

B of long lead times associated with product development and building capacity, a supplier must initiate investment in capacity when the product development effort is ongoing. Because the product is ill defined at this point in time, the buyer is unable to commit to the future terms of trade through a courtenforceable contract. Instead, to provide incentives for capacity investment, the buyer i...

Supply chain coordination has become a critical success factor for supply chain management (SCM). In the past few years, the researchers have widely emphasized that cooperation among supply chain (SC) firms is a key source of competitive advantage. This paper is focused on supply chain coordination from the perspective of inventory management. Li and Liu [1] developed a model for illustrating h...

This paper presents the possible effects of a temporary price discount offered by a supplier on a retailer’s replenishment policy for deteriorating items with linear time dependent demand rate. The optimal ordered quantity of a special order policy for a selected case is obtained by maximizing the total cost saving between special and regular orders for the duration of the depletion time. An al...

With the widespread use of manufacturing philosophies such as Just-In-Time (JIT), emphasis has shifted to the simultaneous consideration of cardinal and ordinal data in supplier selection process. Traditionally, many optimization models of supplier selection assume that the average prices of related expenditures are constant. This is far beyond the real situation. In fact, suppliers usually off...

demand is assumed constant in the classical economic order quantity (eoq) model. however, in the real world, the demand is dependent on many factors such as the selling price, warranty of product and marketing effort. in addition pricing and ordering quantity decisions are interdependent for a seller when demand for the product is price sensitive in the inventory models. these types of models a...

it is assumed in most of the existing models that the items can be stored for an unlimited time to meet the future’s demand and their quality and quantity does not change during that period. nevertheless there are special kinds of products which deteriorate or become unusable (such as food products, alcohol, medicines, etc.). therefore if the rate of deterioration is significantly high, the imp...