High-resolution functional imaging of neural activity in vivo relies on appropriate labeling methods. In this issue of Neuron, Nagayama et al. introduce a simple procedure for staining subsets of neurons with organic calcium indicator dyes via local electroporation. Neuronal populations are sparsely labeled, preserving the ability to resolve calcium signals in dendrites and synaptic structures.

BACKGROUND Over the years, a plethora of frailty assessment tools has been developed. These instruments can be basically grouped into two types of conceptualizations - unidimensional, based on the physical-biological dimension - and multidimensional, based on the connections among the physical, psychological, and social domains. At present, studies on the comparison between uni- and multidimens...

Biodiversity informatics (BDI) information is both highly localized and highly distributed. The temporal and spatial contexts of data collection events are generally of primary importance in BDI studies, and most studies are focused around specific localities. At the same time, data are collected by many groups working independently, but often at the same sites, leading to a distribution of dat...

This Online Appendix contains three sections of supporting materials to our paper “Investor Inattention and the Market Impact of Summary Statistics.” First, we provide details on the construction methodology of our instrument of stale macroeconomic information, the U.S. Index of Leading Economic Indicators (LEI). Second, we provide the theoretical details and derivations of our stylized model o...

Wayfinding is of vital importance if visually impaired pedestrians are to walk by themselves from one place to another, since they must calculate both their orientation and position. Here, a new haptic direction indicator is proposed, which will help blind pedestrians to avoid hazardous areas intuitively and safely by means of haptic navigation. A novel translational force perception method, ca...

adi it ion ally, zero crossings of the second derivative provide edge features for the classification of blurred waveforms. The accuracy of these edge features deteriorates in the case of severely blurred images. In this paper, a new feature is presented that is more resistant to the blurring process, the image, and waveform peaks. In addition, an estimate of the standard deviation of the blurr...

This document specifies a Dynamic Host Configuration Protocol (DHCPv4 and DHCPv6) option containing the civic location of the client or the DHCP server. The Location Configuration Information (LCI) includes information about the country, administrative units such as states, provinces, and cities, as well as street addresses, postal community names, and building information. The option allows mu...

BACKGROUND In 2004, after a series of national initiatives associated with marked improvements in the quality of care, the National Health Service of the United Kingdom introduced a pay-for-performance contract for family practitioners. This contract increases existing income according to performance with respect to 146 quality indicators covering clinical care for 10 chronic diseases, organiza...

Most studies have looked at the distribution of well-being or its change over time in terms of income. However, family wealth is also an indicator of well-being, independent of the direct financial income it provides. There are four reasons. First, owner-occupied housing provides services directly to their owner. Second, wealth is a source of consumption, independent of the direct money income ...

adi it ion ally, the problems of Byzantine agreement, concensus, and interactive consistency are studied in a fully connected network with processors in malicious failure only. Such problems are re-examined with the assumption of malicious faults on both processors and links. The proposed protocols use the minimum number of message exchanges and can tolerate the maximum number of allowable faul...