Recent advances in disease pathogenesis and modern technologies are gradually transforming conventional medicine into personalized medicine. The personalized approach to diagnosis of leukemic patients consists of comprehensive and individualized evaluation based on characteristics of the tumor cell morphology, immunophenotype, cytogenetic and molecular aberrations as well as the patient’s overa...

As Lyme disease spans across the entire body; encompassing all systems; an equally encompassing and individualized treatment path is required to recover health. Functional Medicine 3 is a comprehensive, individualized approach focusing on the interrelated function of the whole person rather then a disease-treatment focus. In my practice, functional medicine provides the context within which to ...

Fibrous dysplasia is a benign bone disorder that most commonly affects craniofacial bones; one or multiple adjacent bones can be involved which can severely deform the skull base. Cerebrospinal fluid leakage in combination with extensive craniofacial fibrous dysplasia is an extremely rare condition that leads to complicated skull base deformation and possible neurovascular structure impingement...

BACKGROUND Despite the existence of effective drug treatments, tuberculosis (TB) causes 2 million deaths annually worldwide. Effective treatment is complicated by multidrug-resistant TB (MDR TB) strains that respond only to second-line drugs. We projected the health benefits and cost-effectiveness of using drug susceptibility testing and second-line drugs in a lower-middle-income setting with h...

In therapy for chronic posttraumatic stress disorder (PTSD), prolonged exposure (PE) to stimuli associated with an original trauma experience is considered a state-of-the-art treatment method. The present case report outlines the use of Foa and Rothbaum’s (1998) manual for this type of treatment in the year-long, 40-session treatment of Caroline, an adult female victim of child sexual abuse. Th...

Individuals with language and cognitive deficits following brain damage likely require long-term rehabilitation. Consequently, it is a huge practical problem to provide the continued communication therapy that these individuals require. The present project describes the development of an impairment-based individualized treatment workflow using a software platform called Constant Therapy. This a...

For a patient who is facing a treatment decision, the added value of information provided by a biomarker depends on the individual patient's expected response to treatment with and without the biomarker, as well as his/her tolerance of disease and treatment harm. However, individualized estimators of the value of a biomarker are lacking. We propose a new graphical tool named the subject-specifi...

Recent development in data-driven decision science has seen great advances individualized making. Given data with individual covariates, treatment assignments and outcomes, researchers can search for the optimal rule (ITR) that maximizes expected outcome. Existing methods typically require initial estimation of some nuisance models. The double robustness property protect from misspecification e...

cow’s milk allergy (cma) is the most frequent food allergy in children and oral immunotherapy (oit) is a promising approach for treatment of patients. the most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. considering that cma varies among patients, an individualized oit protocol would be beneficial to achieve a...