In 13 patients with allergic asthma disodium cromoglycate protected fully only two from an allergen-induced asthmatic attack.Inhalation of disodium cromoglycate did not improve lung function in five patients with long-standing chronic asthma.Previous clinical trials do not show convincing evidence that this drug improves bronchial asthma in a high percentage of cases, but it seems to help a sma...

BACKGROUND Asthma and allergic rhinitis are highly prevalent conditions that cause major illness worldwide. This study aimed to assess the association between allergic rhinitis and asthma control in Peruvian school children. METHODS A cross-sectional study was conducted among 256 children with asthma recruited in 5 schools from Lima and Callao cities. The outcome was asthma control assessed b...

various cross-sectional and longitudinal studies have suggested that synthetic bedding is associated with asthma, allergic rhinitis and eczema while feather bedding seems to be protective. synthetic bedding items have higher house dust mite allergen levels than feather bedding items. this is possibly the mechanism involved although fungal and bacterial proinflammatory compounds and volatile org...

BACKGROUND Despite an increasing recognition that both asthma and allergic rhinitis are serious health disorders in Thailand, their combined effects on patients' quality of life in the Thai population has not been reported. OBJECTIVE The study aimed to evaluate the impacts of allergic rhinitis and asthma on the quality of life of young adolescents in Thailand. METHODS A total of 1,440 pupil...

exercise induced asthma (eia) is a transient increase in airway resistance after intensive exercise and can be measured as a decline in forced expiratory volume in one second (fev1). the condition is due to increased training load and inhalation of cold and dry air. several studies have shown that eucapnic voluntary hyperpnea challenge test (evh test) is a very sensitive and specific diagnostic...

One feature of allergic asthma, the EAR (early allergic reaction), is not present in the commonly used mouse models. We therefore investigated the mediators involved in EAR in a guinea-pig in vivo model of allergic airway inflammation. Animals were sensitized using a single OVA (ovalbumin)/alum injection and challenged with aerosolized OVA on day 14. On day 15, airway resistance was assessed af...

Rourea coccinea (syn. Byrsocarpus coccineus) Schum. and Thonn. (Connaraceae) is a medicinal plant that being used for the treatment of various disorders in Tropical Africa. Previously, we reported anti-inflammatory antioxidant effects ethanolic extract R. root bark (EERc). The present study aimed to test protective potential EERc treatments against ovalbumin-induced airway lung inflammatory inv...

BACKGROUND A close relation between asthma and allergic rhinitis has been reported by several epidemiological and clinical studies. However, the nature of this relation remains unclear. We used the follow-up data from the European Community Respiratory Health Survey to investigate the onset of asthma in patients with allergic and non-allergic rhinitis during an 8.8-year period. METHODS We did...

Upper and lower airways are considered a unified morphological and functional unit, and the connection existing between them has been observed for many years, both in health and in disease. There is strong epidemiologic, pathophysiologic, and clinical evidence supporting an integrated view of rhinitis and asthma: united airway disease in the present review. The term "united airway disease" is o...

PURPOSE Several lines of evidence indicate that the Hippo/Yes-associated protein 1 (YAP1) pathways might play a role in the pathogenesis of asthma. To investigate the possible role of the Hippo/YAP1 pathway in the pathogenesis of asthma or its phenotypes. METHODS The levels of gene expressions of the members of the Hippo/YAP1 were compared. The presence of the proteins of the YAP1 and FRMD6 w...