Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. The purpose of this study was to investigate whether paeonol protected against APAP-induced hepatotoxicity. Mice treated with paeonol (25, 50, 100 mg/kg) received 400 mg/kg acetaminophen intraperitoneally (i.p.) and hepatotoxicity was assessed. Pre-treatment with paeonol for 6 and 24 h ameliorated APAP...

The paper reviews some of the mechanisms implicated in hepatotoxicity, which is induced by an excess lipids. spans a wide variety topics: from molecular lipids, to therapy hyperlipidemia, hepatotoxicity lipid-lowering drugs. NAFLD currently leading cause chronic liver disease Western countries; are only partially understood and there no effective therapeutic interventions. prevalence constantly...

Adverse outcome pathways (AOPs) and their networks are important tools for the development of mechanistically based non-animal testing approaches, such as in vitro and/or silico assays, to assess toxicity induced by chemicals. In present study, an AOP network connecting 14 linear AOPs related human hepatotoxicity, currently available AOP-Wiki, was derived according established criteria. The cha...

The objective of this review is to highlight the continued exclusion of discussion in the literature regarding alternative causes and proper causality assessment of cases of hepatotoxicity when use of dietary supplements is reported. Though independent experts are working diligently to advance the discussion related to alternative causes of hepatotoxicity resulting in idiosyncratic druginduced ...

Hepatoprotective activity of Croton zehntneri Pax & Hoffman (Euphorbiaceae) leaf essential oil (EOCz) was evaluated against single dose of acetaminophen-induced (500 mg/kg, p.o.) acute hepatotoxicity in mice. EOCz significantly protected the hepatotoxicity as evident from the activities of serum glutamate pyruvate transaminase (GPT), serum glutamate oxaloacetate transaminase (GOT) activities, t...

Herbal supplement-induced liver injury represents a growing concern in the body of drug-induced (DILI) literature, with recent studies mainland China, Iceland, and United States reporting estimated rates herb/dietary (HILI) between 1.16-6.38 per 100,000 (Björnsson et al., 2013; Shen 2019; Vega 2017). Notably, 2020 study demonstrated an increasing prevalence hepatotoxicity secondary to herbal di...

Background: Anti-tuberculosis drugs-induced hepatotoxicity is associated with oxidative stress. Curcumin a powerful antioxidant and has been found to protect the liver from damaging effects of The study aimed assess curative protective against induced by anti TB- drugs (Isoniazid-Rifampicin) using an experimental model Albino rabbits. Methods: rabbits(n=24) were divided into four groups. Group ...

Background & Aim: The human body has the liver as one of its largest organs. It serves as the major site for metabolism and excretion. Injury to the liver or impairment of its functions may complicate one’s health and therefore, constitutes one of the serious public health challenges. The ethanol seed extract of Citrus paradisi Macfad (CPE) was carried out to evaluate ...

introduction: the aim of the study was to investigate the effects of curcuma longa (c. longa) extract on adriamycin-induced hepatotoxicity in rat. methods: animals were divided in six groups: control (co), adriamycin (adr), adriamycin with vitamin c (adr+vitc), vitamin c (vit c), c. longa with adriamycin (cl+adr) and without adriamycin (cl-adr). hepatotoxicity was induced by adriamycin 5mg/kg a...

BACKGROUND Herbal and dietary supplements are commonly used throughout the World. There is a tendency for underreporting their ingestion by patients and the magnitude of their use is underrecognised by Physicians. Herbal hepatotoxicity is not uncommonly encountered, but the precise incidence and manifestations have not been well characterised. AIMS To review the epidemiology, presentation and...