نتایج جستجو برای: induced liver injury dili
تعداد نتایج: 1452682 فیلتر نتایج به سال:
Drug induced liver injury (DILI) is a condition with wide clinical spectrum. The diagnosis represents challenge not only due to the large number of known hepatotoxic products but especially when substance involved induce damage. Empagliflozin linked several adverse effects has been convincingly associated DILI. We report case 70-year-old type 2 diabetic woman that presented gastrointestinal sym...
BACKGROUND & AIMS The occurrence of drug-induced liver injury (DILI) is a major issue in all phases of drug development. To identify novel biomarker candidates associated with DILI, we utilised an affinity proteomics strategy, where antibody suspension bead arrays were applied to profile plasma and serum samples from human DILI cases and controls. METHODS An initial screening was performed us...
Among drug-induced liver injuries (DILI), the cholestatic type is second in frequency (from 20 to 40%), most common hepatocellular variant (up 78%). For this reason, practitioners of various specialties, including neurologists and psychiatrists, do not monitor cholestasis parameters, injury with (DILIС) remains unrecognized. The urgency problem great, because deaths DILIС only slightly lower th...
Drug-induced liver injury (DILI) involving the adaptive immune system is a serious complication in both patient treatment and drug development. Flucloxacillin, a -lactam antibiotic effective against -lactamase-producing bacteria, is a common cause of immunological DILI through cholestasis. We have recently isolated CD8+ flucloxacillin-specific T-cells from patients with DILI, which indicates th...
Efavirenz (EFV) is an anti-retroviral drug frequently combined with isoniazid (INH) to treat HIV-1/tuberculosis co-infected patients. Both drugs have been associated with idiosyncratic liver injury (DILI), but combined anti-retroviral and anti-tubercular therapy can increase the risk for DILI as compared to either drug class alone. Because both EFV and INH have been implicated in targeting mito...
background:methotrexate (mtx) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (ra) which can be associated with toxic effects on different organs. this study was designed to investigate the hepatotoxic effects in ra patients treated with mtx. methods: in this cross-sectional observational study, ra patients who received standard do...
AIMS N-acetylcysteine (NAC) may be useful in the management of non-paracetamol drug-induced liver injury (DILI). Our objective was to review systematically evidence for the use of NAC as a therapeutic option for non-paracetamol DILI. METHODS We searched for randomized controlled trials (RCTs) and prospective cohort studies. We searched several bibliographic databases, grey literature sources,...
BACKGROUND Keratin 8 and 18 (K8/K18) cytoskeletal proteins protect hepatocytes from undergoing apoptosis and their mutations predispose to adverse outcomes in acute liver failure (ALF). All known K8/K18 variants occur at relatively non-conserved residues and do not cause keratin cytoskeleton reorganization, whereas epidermal keratin-conserved residue mutations disrupt the keratin cytoskeleton a...
AIMS Liver-enriched microRNA-122 (miR-122) is a novel circulating biomarker for drug-induced liver injury (DILI). To date, miR-122 has been measured in serum or plasma venous samples. If miR-122 could be measured in capillary blood obtained from a finger prick it would facilitate point-of-care testing, such as in resource-limited settings that have a high burden of DILI. METHODS In this study...
Sensitive and predictive DILI (Drug Induced Liver Injury) biomarkers are needed in drug R&D to improve early detection of hepatotoxicity. The discovery of DILI biomarkers that demonstrate the predictive power to identify individuals at risk to DILI would represent a major advance in the development of personalized healthcare approaches. In this healthy volunteer acetaminophen study (4g/day for ...
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