Retinoids are nonsteroidal hormonal compounds related to retinol. They were discovered more than 50 years ago and have various biologic effects. The oral retinoids currently used in dermatology have different indications and include isotretinoin, acitretin, bexarotene, and alitretinoin. We present the case of a patient who developed thrombocytopenia that was probably induced by acitretin. The p...

DW was a born in China with complete unilateral cleft lip and palate. She was placed in an orphanage shortly after birth. At 19 months of age, a family in the United States adopted her, and shortly thereafter, she underwent uneventful cleft lip repair. At 20 months of age she had a positive Mantoux Purified Protein Derivative (PPD) test and was begun on Isoniazid monotherapy for possible latent...

This report describes studies into the pathophysiology of heparin-induced thrombocytopenia. The IgG fraction from each of nine patients with heparin-induced thrombocytopenia caused heparin-dependent platelet release of radiolabeled serotonin. Both the Fc and the Fab portions of the IgG molecule were required for the platelet reactivity. The platelet release reaction could be inhibited by the Fc...