OBJECTIVE To evaluate pre-treatment undernutrition, and folate and B12 deficiency in children with acute lymphoblastic leukemia, and their correlation with complications and outcome of induction chemotherapy. DESIGN Observational study. SETTING Tertiary care teaching hospital in Northern India. PARTICIPANTS 50 children with acute lymphoblastic leukemia. PROCEDURE Children were assessed ...

Patients over age 60 comprise the majority of those diagnosed with acute myeloid leukemia (AML), but treatment approaches in this population are variable, with many uncertainties and controversies. Our group conducted a literature review to summarize the latest information and to develop a consensus document with practical treatment recommendations. We addressed five key questions: selection cr...

BACKGROUND Multiple concepts of combined modality therapy for locally advanced inoperable non-small cell lung cancer have been investigated. These include induction chemotherapy, concomitant chemo-radiotherapy, and radiation only. To date, combined modality therapy specially the use of concomitant chemo-radiotherapy has led to promising results and was shown to be superior to radiotherapy alone...

BACKGROUND The optimal combination of chemotherapy with radiation therapy for treatment locally advanced non-small cell lung cancer (NSCLC) remains an open issue. This randomized phase II study compared gemcitabine in two different schedules and cisplatin - as induction chemotherapy, followed by radiation therapy concurrent with cisplatin and etoposid. PATIENTS AND METHODS Eligible patients h...

Abstract Graft versus host disease (GVHD) is a significant cause of morbidity and mortality following hematopoietic stem cell transplantation (HSCT). While donor T cells have been shown to be instrumental in pathogenesis, prior studies are limited, as assumed depleted by conditioning (chemotherapy ± irradiation) used HSCT. Recent data suggest that skin resident memory survive HSCT humans contri...

BACKGROUND The decision to use universal primary antimould prophylaxis to prevent invasive aspergillosis in patients with acute leukemia depends on the incidence of infection at individual centres. We determined our institution's incidence of invasive aspergillosis among patients who received remission-induction chemotherapy for acute leukemia to evaluate the potential benefits of primary antim...