Background: Areas of microvascular proliferation have been observed in a subpopulation of symptomatic congenital vascular malformations later in life. We investigated whether this angiogenic response is followed by a stage of maturation. Methods: Resections of vascular malformations (n=15), infantile hemangiomas (n=8) and pyogenic granulomas (n=5) were studied. Histopathologically, all lesions ...

BACKGROUND Infantile hemangiomas are common tumors, distinctive for their perinatal presentation, rapid growth during the first year of life, and subsequent involution-and for their expression of a unique immunophenotype shared by placental microvessels. Occasional "hemangiomas" differ from the classic form in presenting fully formed at birth, then following a static or rapidly involuting cours...

AIM To describe how fetal growth and gestational age affect infantile colic, while considering other potential risk factors. STUDY DESIGN A population based follow up study of 2035 healthy singleton infants without any disability born to Danish mothers. Information was collected by self administered questionnaires at 16 and 30 weeks of gestation, at delivery, and 8 months post partum. Infanti...

While >200 types of etiologies have been shown to be involved in the pathogenesis of infantile spasms, the pathophysiology of infantile spasms remains largely elusive. Pre-natal stress and hypothalamic-pituitary-adrenal axis dysfunction were shown to be involved in the development of infantile spasms. To test the genetic association between the CRHR1 gene, which encodes the corticotrophin-relea...

OBJECTIVE To investigate the associations between use of nicotine replacement therapy (NRT) and smoking during pregnancy and infantile colic in the offspring. METHODS We used data from maternal interviews (from pregnancy and at 6 months post partum) from the Danish National Birth Cohort (1996-2002). We included 63 128 live-born singletons with complete information on nicotine exposure during ...

Four cases of late-onset Krabbe's leukodystrophy had varying clinical features. One sibling became wheelchair-bound while another leads an active working life. The computed tomography (CT) scan of a third patient showed occipital demyelination with contrast enhancement identical to that seen in an adrenoleucodystrophy. The fourth was the only patient with peripheral neuropathy. All patients had...

Kanner (1943, 1957) was the first to point out that one particular syndrome of abnormal behaviour could be separated from the previously undifferentiated group of childhood psychoses. Children with the syndrome (called early infantile autism) were distinguished by three outstanding characteristics: lack of responsiveness to other human beings-that is, " autism "-an insistence on the preservatio...

Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by a variable clinical picture and serological abnormalities. Children and adolescents generally have a more severe disease presentation; develop disease damage more quickly than adults with SLE. Diffuse alveolar hemorrhage (DAH) is a rare life-threatening complication in SLE. In this report a case...

PDF created with FinePrint pdfFactory Pro trial version enzyme implicated in neurodegeneration, is localized in neurons and is developmentally regulated in rat brain. The expression of palmitoyl-protein thioesterase is developmentally regulated in neural tissues but not in nonneural tissues. changes in the expression of neuronal ceroid lipofuscinoses-linked proteins. Mol Genet Status epilepticu...

PURPOSE To compare development of acuity in patients with isolated infantile nystagmus and infantile nystagmus associated with a visual sensory defect. METHODS Visual acuities in 57 children (1 month to 4 years of age) with infantile nystagmus were assessed by using Teller acuity cards oriented vertically during binocular viewing. Twenty-two had isolated infantile nystagmus, 21 had albinism, ...