Only three cases of infectious lymphocytosis have been described as such in the English literature. Elsewhere about 70 cases have been described, almost entirely in the American literature. As the disease may be more common in England than the recorded'cases would seem to indicate, it was thought worthwhile to report a case, review the literature and discuss the differential diagnosis with part...

Epsten-Barr virus oropharyngeal shedding has been demonstrated in infectious mononucleosis patients many months after acute illness and long after the disease hallmarks, atypical lymphocytes and heterophile antibody, have disappeared. Extracellular virus is present more frequently in saliva than in other oropharyngeal samples. Prolonged excretion of EBV in asymptomatic carriers explains the dif...

Angioimmunoblastic lymphadenopathy occurred in a 46-year-old man 16 months after an episode of infectious mononucleosis induced by Epstein-Barr (EB) virus. The features of infectious mononucleosis included fever, pharyngitis, lymph gland enlargement, hepatosplenomegaly, hyperbasophilic mononuclear cells, and IgM antibodies to EB virus, although heterophile antibodies were not detected. The illn...

Epstein-Barr is a ubiquitous virus that infects 95% of the world population at some point in life. Although Epstein-Barr virus (EBV) infections are often asymptomatic, some patients present with the clinical syndrome of infectious mononucleosis (IM). The syndrome most commonly occurs between 15 and 24 years of age. It should be suspected in patients presenting with sore throat, fever, tonsillar...

OBSCURE though its ultimate cause may be, awareness of the widespread nature of the changes throughout the body prompts one to be on the lookout for unusual clinical signs in glandular fever. There have been no reports of its ocular manifestations in Great Britain since hyperaemia of the discs was first described by Clemens (1907). The most authoritative and recent account is that of Tanner (19...

A screening test for infectious mononucleosis is described, based on the fact that antibodies against sheep red cells remaining after absorption of the serum by papain-treated sheep red cells appear to be specific for the disease. The test appears to be more useful in diagnosis than classical absorption techniques and has the advantage of being specific while maintaining a high degree of sensit...

Platelet function has been studied in 16 patients with uncomplicated infectious mononucleosis. Some abnormality of platelet aggregation and/or release of platelet factor III or platelet factor IV was found in all patients. Six patients with platelet defects were retested after three to four months and were found to have normal platelet function and appreciably higher platelet counts. Abnormal p...