„ Increasing bacterial resistance to antibiotics makes the management of superficial skin infections a major medical challenge. Antiseptics have broader spectrums of antimicrobial activity and a reduced potential for selection of bacterial resistance, relative to antibiotics. Consequently, antiseptics are appropriate alternatives to antibiotics for the prevention and treatment of superficial sk...

Infection control personnel familiar with the studies underlying recent guideline recommendations for the prevention of intravascular catheter-related infections could conclude that it would be easy to minimize the risk of such infections. Randomized, controlled trials have demonstrated that prepping the skin with chlorhexidine antiseptic can reduce the risk of catheter-related bloodstream infe...

Emergence of new infectious diseases such as tuberculosis, bacterial and fungal diseases have stimulated public interest and inspired commitments by medicinal chemists to control these diseases. Increasing microbial resistance has become a very serious clinical problem for many classes of antibiotics. Therefore, it is an urgent requirement to design and synthesize novel antimicrobial agents to ...

OBJECTIVE This article reviews current research into non-antibiotic treatments for bacterial vaginosis and assesses interest in the use of alternative therapies for women's health in a non-representative sample of women. DESIGN Literature review and online survey. SUBJECTS A convenience sample of 192 women was selected from an online community devoted to the discussion of women's health. ...

The purpose of the study is to give the rising incidence of Salmonellosis and the continuous decrease of sensitivity of Salmonella to a range of antibiotics, the prime importance of the choice of optimal anti-infective chemotherapy in order to prevent the selection of multidrug-resistant strains (MDR). We have studied 54 strains of Salmonella sent for further investigation to "Cantacuzino" NIRD...

What causes it? The most common causes of dysuria are infections, such as bladder infections or urinary tract infections (UTIs). In women, vaginal infections are a common cause. In men, prostate infections can cause it. In both men and women, sexually transmitted infections can cause it. Sometimes using soaps, spermicides, or lotions can cause irritation and pain. Some skin problems can cause d...

The increasing clinical use of artificial medical devices raises the issue microbial contamination, which is a risk factor for occurrence biofilm-associated infections. A huge amount scientific data highlights promising potential essential oils (EOs) to be used development novel antibiofilm strategies. We aimed review relevant literature indexed in PubMed and Embase identify recent directions f...

DXP synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate, an essential precursor in pathogen isoprenoid biosynthesis. The selective inhibition of this ThDP-dependent transformation is a challenging goal in the development of isoprenoid biosynthesis inhibitors. Potent, selective inhibitors could lead to new anti-infective agents. Here, we demonstrate selective inhibition of E. coli...

The need for new antimicrobial agents is greater than ever because of the emergence of multidrug resistance in common pathogens, the rapid emergence of new infections, and the potential for use of multidrug-resistant agents in bioweapons. Paradoxically, some pharmaceutical companies have indicated that they are curtailing anti-infective research programs. We evaluated the United States Food and...

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