UNLABELLED Neuropsychiatric disorders (e.g., autism, schizophrenia) are partially characterized by social cognitive deficits, including impairments in the ability to perceive others' emotional states, which is an aspect of social cognition known as theory of mind (ToM). There is also evidence that inflammation may be implicated in the etiology of these disorders, but experimental data linking i...

Neuromyelitis optica spectrum disorders are rare relapsing inflammatory central nervous system diseases with a heterogenous immunological and clinical spectrum. International collaborations required to: (i) reach better understanding of the disease its subtypes; (ii) develop laboratory imaging biomarkers; (iii) ultimately improve treatments.

BACKGROUND This study sought to evaluate whether risks of diabetes mellitus and cardiovascular disease are elevated across a range of organ-specific and multisystem chronic inflammatory disorders. METHODS AND RESULTS A matched cohort study was implemented in the UK Clinical Practice Research Datalink including participants with severe psoriasis (5648), mild psoriasis (85 232), bullous skin di...

primary hepatic lymphoma is a rare malignancy usually presenting with symptoms of fever, hepatomegaly, jaundice and weight loss. this picture mimics infectious and inflammatory disorders and thus delays the diagnosis. here, we present a 47-year old man with prolonged fever who underwent several investigations and, in the meantime, developed fulminant hepatic failure before the diagnosis could b...

In recent years, there has been a growing number of studies trying to explain the role inflammatory processes in pathogenesis mental disorders, including schizophrenia. Epidemiological evidence supports hypothesis maternal immune activation during pregnancy, which increases risk schizophrenia offspring. Studies searching for potential biomarkers suggest its links with pro-inflammatory cytokines...

changes (bmd) and osteoporosis .helico bacter pylori which is a known cause of gastritis and peptic ulcer osteopprosis is one major cause of bone fracture and subsequent morbidity and mortality in the elderly population. several clinical and demographic parameters including aging, menopause, parity , inflammatory disease, hormonal, gastrointestinal, renal and metabolic disorders like vitamin d ...

introduction: multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae), is a chronic inflammatory diseases and degenerative myelin in the cns. with respect to being the main cause of this disease is unknown; the most common treatments for the disease (ms) with the aim of suppressing harmful inflammatory responses are used. neuro transmitters having immunosup...

Recent studies using small bowel endoscopy revealed that non-steroidal anti-inflammatory drugs including low-dose aspirin, can often induce small bowel injury. Non-steroidal anti-inflammatory drugs-induced small bowel mucosal injury involves various factors such as enterobacteria, cytokines, and bile. Experimental studies demonstrate that both mitochondrial disorders and inhibition of cyclooxyg...

Inflammatory diseases cause health disorders which result in a reduction of the population. That is why this medical problem considered to be very important one. The human immune system responsible for protecting body from infections various origins, while inducing chronic inflammation (characterized by long, often invisible course) can proneness recurrence, complications and resistance therapy...

thrombin is a multifunctional enzyme which has key roles in coagulation cascade and inflammatory events. the pro-inflammatory functions of thrombin occur by different mechanisms including increasing mast cell degranulation, up-regulating the expression of cell adhesion molecules (cams) and promoting the secretion of inflammatory chemokines and cytokines. dysregulated signaling functions of thro...