Despite their importance for biological activity, slower molecular motions beyond the nanosecond range remain poorly understood. We have assembled an unprecedented set of experimental NMR data, comprising up to 27 residual dipolar couplings per amino acid, to define the nature and amplitude of backbone motion in protein G using the Gaussian axial fluctuation model in three dimensions. Slower mo...

We propose a new method for predicting protein secondary structure of a given amino acid sequence, based on a classification rule automatically learned from a relatively small database of sequences whose secondary structures have been experimentally determined. Among the three types of secondary structures, helix, -sheet, and others, we concentrate on the problem of predicting the -sheet region...

Planning board— CHRISTENSEN MOVED THAT CENTRAL BOARD ALLOCATE $?$Q FOR THE PURPOSE OF PUBLISHING AND DISTRIBUTING AN ASUM INFORMATION SHEET TWICE WEEKLY WINTER. QUARTER. PARRY SECONDED. Murphy asked why the amount was not $500 that was mentioned at the Planning Board meeting. Gray said that $250 would be for only Winter Quarter to see how the Information Sheet went. Gray also said that the shee...

Weak gravitational lensing is considered to be one of the most powerful tools to study the mass and the mass distribution of galaxy clusters. However, the mass-sheet degeneracy transformation has limited its success. We present a novel method for a cluster mass reconstruction which combines weak and strong lensing information on common scales and can, as a consequence, break the mass-sheet dege...

The GMC states that "Trainees in hospital posts must have well organised handover arrangements, ensuring continuity of patient care[1]". In the Belfast City Hospital throughout the day there can be multiple new medical admissions. These can be via the GP Unit, transfers for tertiary care, and transfers due to bed shortages in other hospitals. Over the course of 24 hours there can be up to four ...

Whether credit market participants process disclosure and recognition of pension information differently has not been fully explored. To fill this gap, study investigates whether the change in a accounting standard related to rule influences firms’ risk Japan. Statement No. 26, Accounting Standard for Retirement Benefits, stipulates that firms recognize previously disclosed on balance sheet. Em...

We present novel empirical evidence on the use of off-balance sheet financing by publiclytraded, U.S. nonfinancial firms. We find that about 5 percent of nonfinancial firms reported using a special purpose financing vehicle (SPV) to finance receivables in 2006. At the origination of the off-balance sheet financing program, firms experienced abnormal increases in stock prices on the order of 2 p...

A layered construct was developed by combining a porous polymer sheet and a cell sheet as a tissue engineered vascular patch. The primary objective of this study is to investigate the influence of mesenchymal stem cells (MSCs) sheet on the tensile mechanical properties of porous poly-(l-lactide-co-ε-caprolactone) (PLCL) sheet. The porous PLCL sheet was fabricated by the solid-liquid phase separ...

IMPORTANCE Isotretinoin, a known teratogen, is strictly regulated through the iPLEDGE program. However, isotretinoin-exposed pregnancies continue to occur. OBJECTIVE To evaluate an information sheet's effect on women's contraceptive knowledge. DESIGN, SETTING, AND PARTICIPANTS Women aged 18 to 45 years visiting a dermatology practice completed anonymous surveys assessing their knowledge of ...