The suspicion that a newly developed detergent ingredient, sodium iso-nonanoyl oxybenzene sulphonate (SINOS), was inducing asthma among a workforce led to a series of inhalation challenge tests to determine the specificity and dose response characteristics of its asthma provoking properties. Three previously exposed workers, three non-exposed non-asthmatic controls, and three non-exposed asthma...

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We agree with McClean and his co-workers (McClean et al., 2004) that urinary 1-hydroxypyrene concentration is a useful measure of total absorbed dose of polycyclic aromatic hydrocarbons (PAHs). Many occupational health studies have reported low correlations between inhalation exposures and urinary 1-hydroxypyrene levels, suggesting that other exposure routes (in particular dermal, but also inge...

background the purpose of this study was to examine the relationship between the type of inhaled medication, length of use, dosing, the inhaler use technique and the severity and duration of disease on the dental caries of asthmatic patients. objectives in the present study, the frequency of dental caries in the asthmatic patients and control group was examined. in addition the possible associa...

objective(s): nanomaterials, especially silver nanoparticles (ag-nps), are employed in an increasing number of commercial products. this has led to an ever growing exposure of human beings to this substance. the first purpose of the nano committee of food and drug administration of the islamic republic of iran (ifda) is developing guidelines to assess and approve commercial nano-health products...

Hypoxic Pulmonary Vasoconstriction (HPV) was first reported by Bindsley et al. in adult patients and was managed using double lumen catheters to ventilate one lung with 100% oxygen and the other with 95% N2 and 5% oxygen during intravenous barbiturate and fentanyl anesthesia. However, ‘‘HPV inhibition’’ has predominantly been attributed to the use of inhalation agents and is considered as a cau...

Two major factors affect drug delivery with nebulizers: usage time and droplet size. Unlike other inhalation devices, nebulizers provide continuous delivery instead of a pre-metered dose of drug. Once loaded and activated, a nebulizer operates with the user breathing normally so that the patient’s breathing profile and usage time determine the amount of drug received. As with other inhalation p...

We examined for myocardial ischemia induced by continuous inhalation of fenoterol in children with severe acute asthma. Thirty children with severe acute asthma were evaluated for signs of myocardial ischemia when treated with 0.5 mg kg dose (maximum 15 mg) of inhaled fenoterol for one hour. The heart rate was measured before and after inhalation. Cardiac enzymes (creatine kinase, creatine kina...

Carbon nanotubes are shaped like fibres and can stimulate inflammation at the surface of the peritoneum when injected into the abdominal cavity of mice, raising concerns that inhaled nanotubes may cause pleural fibrosis and/or mesothelioma. Here, we show that multiwalled carbon nanotubes reach the subpleura in mice after a single inhalation exposure of 30 mg m(-3) for 6 h. Nanotubes were embedd...

Propylene glycol phenyl ether exhibits low acute toxicity by the oral, and inhalation routes. The oral LD50 in rats exceeds 2000 mg/kg (1 death from 10 subjects occurred at this highest dose tested); and the 4-hour inhalation LC50 in rats was greater than 5400 mg/m (no deaths). PPh was severely irritating to the eyes but non-irritating to skin in rabbits tested and evaluated according to the Dr...