introduction: low-frequency stimulation (lfs) has a delaying effect on kindled seizures acquisition. in the present study we examined the role of galanin receptors in the inhibitory effects of lfs on kindled seizures induced by electrical stimulation of perforant path. methods: animals were stimulated daily at the ad threshold intensity with a rapid kindling procedure. lfs was applied immediate...

background: salvia mirzayanii, a native plant to iran, is shown to have immunomodulatory effects on lymphocyte proliferation. objective: to identify the bioactive immunomodulatory compound(s) present in s. mirzayanii. methods: the crude extract was fractionated to five fractions in two steps using different solvents. the fractions were subjected to bioassay-guided fractionation. all the fractio...

galbanic acid, a sesquiterpene coumarin from ferula szowitsiana , and conferol, another sesquiterpene coumarin from f. badrakema , were evaluated for their effects on the reversal of multi-drug resistance in clinical isolates of staphylococcus aureus and escherichia coli , respectively. neither galbanic acid (up to 1000 μg/ml) nor conferol (up to 400 μg/ml) by itself shows any antibacterial act...

conclusions shiitake essential oil is an effective anti-bacterial and anti-biofilm agent on important oral pathogens and has a possible therapeutic potential as an oral anti-biofilm agent. results no inhibitory effect was observed on f. nucleatum biofilms (p > 0.05). significant disruptive properties on a. actinomycetemcomitans at values lower than the mic (3.90 µg/ml) was detected (p < 0.05). ...

Purpose: In this study, we have focused on antibacterial effect of newly synthesized thiazole, imidazole, and tetrahydropyrimidine derivatives in Iran on listeria monocytogenes. Materials and Methods: For evaluation of antibacterial effect, the disk diffusion method was applied to measure the growth inhibition zone diameter and broth micro dilution was performed to determine the minimum inhibit...