A major question about the mechanism of the myosin ATPase is how much of the fluorescence change which accompanies the binding of ATP to myosin is due to the conformational change induced by ATP and how much is due to the subsequent hydrolysis of ATP in the initial Pi burst. Several laboratories have suggested that the maximal rate of the fluorescence change represents the rate of the irreversi...

Considering the potential of nanostructured titanium dioxide layers as drug delivery systems, it is advisable to indicate possibility creating a functional system based on anodic TiO2 for celecoxib an alternative anti-inflammatory and its inclusion complex with β-cyclodextrin. First, optimal composition celecoxib—β-cyclodextrin complexes was synthesized determined. The effectiveness complexatio...

Controlling drug release using a nanocomposite method is crucial; however, burst must be avoided in order to obtain effective controllable release. In this study, poly(vinyl) alcohol/polyoxalate/Span-80 (PVA/ POX/ Span-80) composite nanofibers loaded with Rhodamine B were produced emulsion electrospinning. The objective of work was evaluate the cooperative roles POX and Span-80 on nanofibrous s...

The extreme energetics of the gamma-ray burst (GRB) 990123 has revealed that some of GRBs emit quite a large amount of energy, and total energy release from GRBs seems to change from burst to burst by a factor of 10–10 as Eγ,iso ∼ 10 52−55 erg, where Eγ,iso is the observed GRB energy when radiation is isotropic. If all GRBs are triggered by similar events, such a wide dispersion in energy relea...

Microparticles were produced by spray-drying from a high molecular weight polylactide (PLA R207) for the development of long-lasting controlled release systems of vaccines, which may be designed to obviate the need for booster doses. The current investigation considered the effect of both technological parameters (inlet air temperature and spray rate of feed) and polymeric solutions (polymer co...

We report in this paper the results of a study carried out to analyse the acoustic and perceptual characteristics of Italian stop consonants. The aim of this study is twofold: give an acoustical description of Italian stops and investigate which are the perceptual cues relative to their place of articulation. From the acoustic point of view we report: the measurements relative to the length of ...

The goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. Rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. The mesoporous silica nanoparticles were prepared by using Tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant); The prepared nanoparti...

Dexamethasone, a steroidal anti-inflammatory drug, was incorporated into porous biodegradable polymer scaffolds for sustained release. The slowly released dexamethasone from the degrading scaffolds was hypothesized to locally modulate the proliferation and differentiation of various cells. Dexamethasone containing porous poly(D,L-lactic-co-glycolic acid) (PLGA) scaffolds were fabricated by a ga...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...