The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viab...

Injectable hyaluronic acid (HA) derivatives are the most used reabsorbable dermal fillers for soft tissue augmentation today and their utilization is considered safe. We report a cutaneous granulomatous reaction that developed in a woman 5 weeks after the first treatment with a nonanimal HA derivative for the correction of facial wrinkling. We describe the clinicopathological findings and cours...

This article focuses on the discussion of the risks, benefits, and limitations of the three principal methods for facial volumization: fat grafting, injectable fillers, and alloplastic implants. By understanding these issues, a surgeon can better discuss what would be ideal for a particular patient. Fat grafting offers, the most cost-effective solution to a patient with sufficient volume loss. ...

Enolase 1 (Eno1p) of Candida albicans is an immunodominant antigen. However, conventional technologies for preparing an injectable vaccine require purification of the antigenic protein and preparation of an adjuvant. To develop a novel type of oral vaccine against candidiasis, we generated Saccharomyces cerevisiae cells that display the Eno1p antigen on their surfaces. Oral delivery of the engi...

Quinacrine Hydrochloride (QH) tablets were originally marketed in the United States in the early 1930s for the treatment of malaria. The drug was used extensively during World War II for this indication and was typically administered in a dose of 100-200 mg per day taken orally. In 1964, an injectable form of Quinacrine was approved for the treatment of recurrent ascites associated with several...