We provide a theoretical framework to contribute to the current debate regarding the tendency of pharmaceutical companies to direct their R&D toward marketing products that are "follow-on" drugs of already existing drugs, rather than toward the development of breakthrough drugs. We construct a model with a population of patients who can be treated with drugs that are horizontally and vertically...

Web publishers frequently integrate third-party advertisements into web pages that also contain sensitive publisher data and end-user personal data. This practice exposes sensitive page content to confidentiality and integrity attacks launched by advertisements. In this paper, we propose a novel framework for addressing security threats posed by third-party advertisements. The heart of our fram...

In this paper, we describe a Conversational Interaction framework as an innovative and natural approach to facilitate easier information access by combining web search and recommendations. This framework includes an intelligent information agent (Cobot) in the conversation that provides contextually relevant social and web search recommendations. This setup leverages the information discovery p...

Although a growing body of research is developing to address the different e-business practices in the electronic marketplace, e-tailing strategies have only been investigated as part of the study of general e-business strategies. However, researchers recognise that innovative and unique modes of e-tailing operations have emerged in recent years. Therefore, this paper introduces an organising f...

This paper presents a flexible framework for interactive search in image retrieval systems. Our approach allows for the visual structure change in order to produce coherent layouts, which highlight the most relevant results according to user needs. This innovative framework is flexible in the sense it supports the dynamic creation of several hybrid visual designs, based on the combination of di...

The protection of the environment through realization sustainable development objectives represents a national priority for Republic Moldova. Polluter pays principle and precautionary principles are clearly stated across special laws on environmental sub-domains. Implementation innovative engineering solutions in Moldova presumes that imported equipment does comply with country’s legal framewor...