La supresión de moléculas ácido ribonucleico mensajero (ARNm) mediante ARN interferente (ARNi) se ha propuesto como método control insectos plagas. El ARNi impide el desarrollo morfológico y funcional los considera altamente específico. En este estudio buscaron receptores insulina (InR) en Brevicoryne brassicae L. (Hemiptera: Aphididae) a partir del ARNm pulgones, primer paso para diseño poster...

BACKGROUND Improved control of oral anticoagulation reduces adverse events. A program of quality measurement is needed for oral anticoagulation. The interval until the next test after an out-of-range International Normalized Ratio (INR) value (the "follow-up interval") could serve as a process of care measure. METHODS AND RESULTS We studied 104 451 patients cared for by 100 anticoagulation cl...

BACKGROUND The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN), catalyzes the integration of viral DNA into the host cell genome. IN catalyzes the first step of the integration process, namely the 3'-end processing in which IN removes a pGT dinucleotide from the 3' end of each viral long terminal repeat (LTR). Following nuclear import of the viral preintegration complex, the ...

Background and Objectives: Optimal international normalized ratio (INR) in elderly atrial fibrillation (AF) patients at higher risk of hemorrhagic events remains unclear. We investigated the efficacy and safety of low-intensity warfarin therapy (target international normalized ratio [INR], 1.6–2.6) in elderly Korean patients with nonvalvular AF (NVAF). Subjects and Methods: We enrolled 528 NVAF...

BACKGROUND & OBJECTIVES There is paucity of studies on the quality of anticoagulation in neurological patients from India. This study evaluates the quality of oral anticoagulation therapy in neurology patients. METHODS Consecutive patients attending a tertiary care neurology service in north India who were prescribed oral anticoagulant (OAC), were included. Their international normalized rati...

BACKGROUND Warfarin is a key element in therapy for atrial fibrillation, deep venous thrombosis (DVT), stroke (cerebrovascular accident) and cardiac valve replacement. Often, patients' warfarin blood levels are not tightly controlled with regard to accepted therapeutic ranges, by virtue of the drug's unpredictable nature. METHODS The authors searched 16,017 active clinical charts for active p...

Vitamin K antagonist (VKA) frequently fails to prevent cerebral infarction, with 30% of VKA-treated patients experiencing ischemic stroke despite an international normalized ratio (INR) of ≥ 2 [1] . Intravenous (IV) thrombolysis is only recommended for patients with an INR of <1.7 [2] . Indeed, experimental results confirmed the high risk of post-thrombolytic hemorrhages at therapeutic INR leve...