background : anopheles stephensi is a sub-tropical species and has been considered as one of the most important vector of human malaria throughout the middle east and south asian region including the malarious areas of southern iran. current reports confirmed an. stephensi resistance to temephos in oman and india. however, there is no comprehensive research on mechanisms of temephos resistance ...

objective(s):the present study was undertaken to determine the effects of acute exposure to malathion on oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of adolescent male mice. materials and methods: thirty two adolescent male mice at pubertal age were treated with 500 mg/kg body weight (bw) of malathion for three days. after exp...

Background: Glutamate is essential to learning and memory as an excitatory neurotransmitter. This study evaluated the atrazine effect on the hippocampus and examined the mitigative role of avocado oil against the neuronal degeneration and behavioral deficits in Wistar rats. Methods: Fifty adult male Wistar rats were divided into four groups of ten. Group 1 (controls) received 0.5 ml distilled ...

Background: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by decreased cognitive function in patients due to forming Aβ peptides and neurofibrillary tangles (NFT) in the brain. Therefore, the need to develop new treatments can reduce this risk. Acetylcholinesterase is one of the targets used in the design of new drugs for the treatment of AD. The researchers obtain new i...

Acetylcholinesterase, an erythroid marker constitutively expressed in K-562 cells, can be further induced by sodium butyrate. The highest level of acetylcholinesterase induction is reached in approximately equal to 3 days, in parallel with increased hemoglobin expression. Acetylcholinesterase induction is reversible, and repeated addition of butyrate is necessary to maintain a high level of the...

fenpropathrin is a new pyrethroid insecticide used to control crop pests. the aim of this study was to evidence fenpropathrin-induced oxidative stress and alterations in biochemical parameters in the freshwater fish, alburnus mossulensi s. total antioxidant capacity, malondialdehyde (mda), catalase activity (cat), aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosph...

Objective(s): Alzheimer’s disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of n...

background: malaria is the most important vector-borne disease in many tropical countries all over the world. because of the widespread use of pyrethroid insecticide treated mosquito nets in the world, the effects of excito-repellency (er) phenomenon of pyrethroids against main malaria vector, anopheles stephensi were studied. methods: the er phenomenon of three concentrations of two synthetic ...

Given extensive use of pesticides in agriculture, there is concern for unintended consequences to non-target species. The freshwater amphipod, Hyalella azteca has been found show resistance the organophosphate (OP) pesticide, chlorpyrifos, resulting from an amino acid substitution acetylcholinesterase (AChE), suggesting a selective pressure pesticide exposure. Since resistant organisms can surv...