Bisphosphonates are currently the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia. These compounds have high affinity for calcium ions and therefore target bone mineral, where they are internalized by bone-resorbing osteoclasts and inhibit osteoclast function. Nitrogen-containing bisphosphona...

Antioxidative properties of extracts from plants have become a great interest due to their possible uses as natural additives to replace synthetic ones. The antioxidant potential of the plant extracts resulted by DPPH, ABTS and FRAP assays indicated that the extracts not only possess antioxidant activity but also the free radical scavenger capability. The utility and choice of in silico screeni...

Lanosterol Synthase is an attractive target for antihypercholesterolemeic drug design. A set of 26 molecules having lanosterol synthase inhibitory activity was used for pharmacophoric hypothesis and atom based QSAR analysis. Inhibitory concentrations (pIC50) of these compounds were ranged from 7.452 to 8.721. Pharmacophoric hypothesis AAHPR.174 had the best survival score of 3.560. On the basis...

BACKGROUND Arabitol dehydrogenase (ArDH) is involved in the production of different sugar alcohols like arabitol, sorbitol, mannitol, erythritol and xylitol by using five carbon sugars as substrate. Arabinose, d-ribose, d-ribulose, xylose and d-xylulose are known substrate of this enzyme. ArDH is mainly produced by osmophilic fungi for the conversion of ribulose to arabitol under stress conditi...

The Human papillomavirus (HPV) E6 protein is one of the oncoproteins encoded by the virus. Inorder to understand the mechanism by which E6 interacts with the host cellular proteins to trigger the cascade of cancer cell transformation. STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) is a biological database has been used to model the pathway of the proteinprotein interaction...

The Tuberculosis is the classical human mycobacterial disease, caused by Mycobacterium Tuberculosis. Mycobacterium tuberculosis is a facultative intracellular pathogen that has evolved the ability to survive and multiply within human macrophages. These bacteria comprise of significant proteins, which were involve in the pathogenesis and regulation of cell activity. Thus there arises the need to...

In recent years, clustering analysis has even become a valuable and useful tool for insilico analysis of microarray or gene expression data. Although a number of clustering methods have been proposed, they are confronted with difficulties in meeting the requirements of automation, high quality, and high efficiency at the same time. In this chapter, we discuss the issue of parameterless clusteri...

The IS6110 belongs to the family of insertion sequences (IS) of the IS3 category. This insertion sequence was reported to be specific for Mycobacterium tuberculosis complex and hence is extensively exploited for laboratory detection of the agent of tuberculosis and for epidemiological investigations based on polymerase chain reaction. IS6110 is 1361-bp long and within this sequence different re...

Benzimidazoles are classified as a category of heterocyclic compounds. Molecules having benzimidazole motifs show promising utility in organic and scientific studies. A series mono-substituted benzimidazoles were synthesized by ZnO-NPs via cyclocondensation between substituted aromatic aldehydes o-phenylene diamine. The compounds characterized compared with the traditional methods. nano-catalyz...