IN the first installment of this two-part communication, we reviewed the indications for an implanted pacemaker or internal cardioverter–defibrillator (ICD), provided a brief overview of how a device is selected, and described the basics of pacemaker and ICD design and function. Here we discuss specific device malfunction, electromagnetic and mechanical interference, and management for patients...

No matter what business you’re in, you’re also in the software business. But where are we heading? This 50th installment of Software Technology tries to look into the future. To mitigate bias, I spoke with many software business leaders around the world. They pointed to ve success factors that will advance the software business. They left unaddressed whether software will evolve humankind to Hu...

This is the second installment to the project initiated in [Ma3]. In the first Part, I argued that both philosophy and technique of the perturbative renormalization in quantum field theory could be meaningfully transplanted to the theory of computation, and sketched several contexts supporting this view. In this second part, I address some of the issues raised in [Ma3] and provide their develop...

We are pleased to present a series of Annotated Classics celebrating 40 years of exciting biology in the pages of Cell. This installment revisits “Genetic Control of Programmed Cell Death in the Nematode C. elegans” by Hilary M. Ellis and H. Robert Horvitz. Here, David Vaux comments on the work that first demonstrated that cell death was controlled by a genetic program by identifying genes that...

This is the third installment in a series of papers on algebraic set theory. In it, we develop a uniform approach to sheaf models of constructive set theories based on ideas from categorical logic. The key notion is that of a “predicative category with small maps” which axiomatises the idea of a category of classes and class morphisms, together with a selected class of maps whose fibres are set...

Drosophila, Wnt, FGF, Jak/Stat, Rho, Rac, RhoGEF, Pebble, Naked Cuticle The site for the latest installment of the Fly Meeting (March 7–11) was downtown Philadelphia. The conference offered an illustration of all that is great about the Drosophila field bringing together evolutionary biologists, immunologists and everyone in between. Here I will provide a small sample of several advances from t...

This article is the second installment in a series on the Berkovich ramification locus for nonconstant rational functions φ ∈ k(z). Here we show the ramification locus is contained in a strong tubular neighborhood of finite radius around the connected hull of the critical points of φ if and only if φ is tamely ramified. When the ground field k has characteristic zero, this bound may be chosen t...

This report describes the culmination of the 13th installment of the “Adaptive Computing (and Agents) for Enhanced Collaboration” (ACEC) track. ACEC focuses on collaborative computing that occurs dynamically among webaccessible software systems and devices. The articulation of these network artifacts must be controlled by adaptive, intelligent control mechanisms, sometimes realized as agents. A...

We are pleased to present a series of Annotated Classics celebrating 40 years of exciting biology in the pages of Cell. This installment revisits “Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One within a Transmembrane Segment” from the Brown and Goldstein lab. Here, Matthew Freeman comments on the elucidation of regulated two-step proteolysis of th...

Ask CaJEM ments of various elements of whole blood have been studied and well-documented 2. There is a linear relationship between the attenuation of In this issue we present our opening installment blood and hemoglobin and hematocrit levels2* 3. of "Ask CaJEM", a format for you to find concise Additionally, it has been established that plasma, responses to clinical questions that are not easil...