نتایج جستجو برای: intensive glycemic control

تعداد نتایج: 1449754  

Journal: :The Journal of trauma 2009
Heather F Pidcoke Sandra M Wanek Laura S Rohleder John B Holcomb Steven E Wolf Charles E Wade

BACKGROUND Hyperglycemia is associated with increased mortality in the severely injured; intensive insulin protocols reduce mortality, improve wound healing, and decrease susceptibility to infection. High glucose variability creates challenges to glycemic control and may be a marker of poor outcome. We wondered whether glycemic variability alone might identify patients at higher risk of death. ...

Journal: :Journal of the American College of Cardiology 2009
Raffaele Marfella Clara Di Filippo Michele Portoghese Franca Ferraraccio Maria Rosaria Rizzo Mario Siniscalchi Emilio Musacchio Michele D'Amico Francesco Rossi Giuseppe Paolisso

OBJECTIVES We analyzed the molecular mechanisms evoked by tight glycemic control during post-infarction remodeling in human hearts. BACKGROUND The molecular mechanisms by which tight glycemic control improves heart remodeling during acute myocardial infarction (AMI) are still largely unknown. METHODS Eighty-eight patients with first AMI undergoing coronary bypass surgery were studied: 38 no...

2010
Aramesh Saremi Thomas E. Moritz Robert J. Anderson Carlos Abraira William C. Duckworth Peter D. Reaven

OBJECTIVE To determine the predictors of progression of calcified atherosclerosis and the effect of intensive glycemic control on this process in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS As part of the Risk Factors, Atherosclerosis, and Clinical Events in Diabetes (RACED) substudy of the Veterans Affairs Diabetes Trial (VADT), 197 and 189 individuals with type 2 diabetes rec...

2010
Scott D. Solomon

Diabetes mellitus is a well-established risk factor for virtually all cardiovascular outcomes, with clinical trials and observational studies demonstrating greater mortality, more myocardial infarctions, and more episodes of heart failure in diabetic than in nondiabetic individuals.1–6 Moreover, diabetes mellitus is often associated with other cardiovascular risk factors, including hypertension...

Journal: :Circulation 2009
Jay S Skyler Richard Bergenstal Robert O Bonow John Buse Prakash Deedwania Edwin A M Gale Barbara V Howard M Sue Kirkman Mikhail Kosiborod Peter Reaven Robert S Sherwin

Diabetes is defined by its association with hyperglycemiaspecific microvascular complications; however, it also imparts a 2to 4-fold risk of cardiovascular disease (CVD). Although microvascular complications can lead to significant morbidity and premature mortality, by far the greatest cause of death in people with diabetes is CVD. Results from randomized controlled trials have demonstrated con...

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