BACKGROUND The findings of interim fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) predict progression-free survival of patients with Hodgkin's lymphoma. Historically, the assessment was based on a static all-or-none scoring system. However, the clinical significance of any positivity in interim FDG-PET/CT has not been defined. DESIGN AND METHODS Ninety-six patients w...

The purpose of this study was to obtain normal hearing thresholds for an ER-3A insert earphone as a contribution for future standardization and for comparison with previous studies and interim ANSI and ISO insert earphone reference equivalent threshold sound pressure levels (RETSPLs). Hearing thresholds were obtained on each ear of 48 normal-hearing subjects from 125 to 8000 Hz using ER-3A and ...

Therapy of Hodgkin disease (HD) is designed to prolong progression-free survival and minimize toxicity. The best regimen to achieve this has not yet been defined. A total of 108 patients with newly diagnosed HD and adverse prognostic factors were prospectively studied between 1999 and 2004. They were assigned to therapy according to defined risk stratification. Patients were defined depending o...

FDG-PET has recently emerged as an important tool for the management of Hodgkins lymphoma. Although its use for initial staging and response evaluation at the end of treatment is well established, the place of interim PET for response assessment and subsequent treatment tailoring is still quite controversial. The use of interim PET after a few cycles of chemotherapy may allow treatment reductio...

Introduction The International scoping study of a future Neutrino Factory and Super-beam Facility (ISS) was established at NuFact 05 to survey the possibilities available for a future complex for precision neutrino physics to succeed the super beam experiments (T2K in Japan and Noνa in the USA) currently under construction. The possibilities centre around developments of the superbeam concept w...

Recently Kajii and Ui [17] proposed to characterize interim efficient allocations in an exchange economy under asymmetric information when uncertainty is represented by multiple posteriors. When agents have Bewley’s incomplete preferences, Kajii and Ui [17] proposed a necessary and sufficient condition on the set of posteriors. However, when agents have Gilboa–Schmeidler’s MaxMin expected utili...

We develop a model of two-stage cumulative research and development (R&D), in which one Research Unit (RU) with an innovative idea bargains to license her nonverifiable interim knowledge exclusively to one of two competing Development Units (DUs) via one of two alternative modes: an Open sale after patenting this interim knowledge, or a Closed sale in which precluding further disclosure to a co...

CKD is a risk factor for heart failure, but there is no data on the risk of ESRD and death after recurrent hospitalizations for heart failure. We sought to determine how interim heart failure hospitalizations modify the subsequent risk of ESRD or death before ESRD in patients with CKD. We retrospectively identified 2887 patients with a GFR between 15 and 60 ml/min per 1.73 m2 referred between J...

Primary mediastinal B-cell lymphoma (PMBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that arises in the mediastinum from B-cells of thymic origin. Optimal management of patients with PMBL remains controversial. The present study evaluates outcomes of 27 PMBL patients treated with R-CHOP with or without radiation therapy (RT). It investigates the role of both interim and posttreatmen...

Preface On its way to its current form this report has received significant input from a considerable number of experts. The " First Interim Report " which basically dealt with emission estimates and projections has been significantly amended to also cover abatement options and associated costs. Comments on the " First Interim Report " were given by representatives of the European Commission at...