Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 (AMP-IBP5) is expressed in keratinocytes and displays both antimicrobial immunomodulatory properties. In contrast to many peptides (AMPs), factor-binging 5, the parent of AMP-IBP5, downregulated psoriasis, an inflammatory skin disease characterized by epidermal hyperplasia, erythematous plaques, abnormal differentia...

Ulcerative colitis is chronic and recurrent disease of the gastrointestinal tract with uncertain etiology and incomplete treatment options. N-methyl-d-aspartate (NMDA) receptor suppression has shown anti-inflammatory effects in vitro and in vivo. The aim of present study was to evaluate the role of dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist, on TNBS (trinitrobenzene sulfoni...

Following a single intra-articular injection of an adenoviral vector capable of driving the protein expression of interleukin-1 receptor antagonist we demonstrated a decrease in lameness and decreased synovitis and osteoarthritis using gene therapy. Author’s address: Equine Orthopaedic Research Laboratory, Department of Clinical Sciences, Colorado State University, 300 West Drake, Fort Collins,...

Abstract Introduction The risk factors that collectively define metabolic syndrome (MetS) are common in heart failure (HF) patients. More research is needed to elucidate the individual role of MetS pathophysiology HF. Purpose study investigates differences biomarker profiles HF patients with and without MetS. Methods results prevalence was 468 1103 (42.4%) index cohort 615 1433 (42.9%) validati...

In this study, we report a total of 292 mouse embryos cultured on Vero cell monolayers and 77 embryos cultured in medium alone at different preimplantation stages examined individually for embryonic mRNA of beta-actin, interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (icIL-1ra) and interleukin-1 receptor type I (IL-1RtI) using reverse transcription and two-step polymerase chain r...

Circulating levels and role of IL-6, IL-1ra, TNFsr-II and CRP in patients with heatstroke is not fully known. This study correlated levels of these mediators with outcome in 26 patients. In survivors (n=20), IL-6 concentration declined on cooling, whereas in non-survivors levels continued to increase at 6 h following admission before declining. Admission TNFsr-II concentrations in survivors wer...

Our objective was to analyse the relationship between circulating cytokines, autoantibodies, acute phase reactants, and disease activity in DMARDs-naïve rheumatoid arthritis (RA) patients (n = 140). All cytokines were significantly higher in the RA cohort than in healthy controls. Moderate-to-strong positive intercorrelations were observed between Th1/Th2/macrophage/fibroblast-derived cytokines...

Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37). Members of the IL-1 Receptor (IL-1R) family include six receptor chains forming four signaling receptor...