The development of effective and well-tolerated biologic therapies has advanced the management of psoriasis by enabling clinicians to treat underlying disease mechanisms. Biologics approved for the treatment of moderate-to-severe psoriasis include three tumor necrosis factor alpha inhibitors and an interleukin-12/interleukin-23 inhibitor. The establishment of the immunological basis of psoriasi...

IL-23/IL-17 axis has been identified as major factor involved in the pathogenesis of several autoimmune diseases; yet its pathogenetic role in pemphigus vulgaris (PV) remains controversial. The aim of this research was to investigate the potential role of IL-23/IL-17 axis in the immunopathogenesis of PV, and correlation between IL-23+ cells and IL-17+ cells was also evaluated. For this purpose,...

Purpose: The aim of this study was to evaluate histologically and immunohistochemically the cytoprotective effects thymoquinone (THQ) against isoproterenol (ISO)-induced aortic tissue damage.
 Materials Methods: Rats were divided into four groups (n=8). Control group (Control); untreated rats, Thymoquinone (THQ); 20 mg / kg intragastrically (ig) THQ at 24 hour intervals for 8 days, Isoprot...

objective: macrophages influence their environment and surrounding immune cells as soon as stimulators affect them. different sources of macrophages induce different reactions in their neighboring immune cells,which result in non-uniform immunologic outcomes. in this experimental research, we compare the behavior of peritoneal macrophages to lipopolysaccharide (lps) stimulation from balb/cmice ...