Abstract Regulatory T cells (Tregs) are potent immune suppressors and critical to the maintenance of immunological tolerance. Interleukin 2 (IL-2) is essential for Treg survival, expansion, phenotypic stability, suppressive function. However, Tregs do not produce IL-2 dependent on exogenous sources IL-2. This poses a significant challenge cell therapies in tissues with no or limited availabilit...

The cytokine interleukin (IL)-11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention. We used combinatorial methods engineer IL-11 variant that binds with higher affinity the receptor stimulates enhanced receptor-mediated cell signaling. Introduction of two additional point mutatio...

1. David D, Bani L, Moreau J-L, Demaison C, Sun K, Salvucci O, Nakarai T, de Montalembert M, Chouaib S, Joussemet M, Ritz J, Thèze J: Further analysis of interleukin-2 receptor subunit expression on the different human peripheral blood mononuclear cell subsets. Blood 91:165, 1998 2. Bani L, David D, Moreau J-L, Cayota A, Nakarai T, Ritz J, Thèze J: Expression of the IL-2 receptor g subunit in r...

The purposes of this study were t o examine the biologic effects of the engagement of the interleukin-7 receptor (IL-7R) with recombinant human interleukin-7 (rhlL-7) in immunophenotypically distinct T-lineage acute lymphoblastic leukemia (ALL) blasts and t o elucidate the biochemical nature of the IL-7R-linked transmembrane signal in rhlL-7responsive T-lineage ALL blast populations. In the abs...

Background: Interleukin (IL)-23 has an important role in tumor immune regulation. Objective: To investigate the possible association of interleukin-23 receptor (IL23R) gene variants rs1884444, rs10889677 and rs11209026 with development of acute lymphoblastic leukemia (ALL). Methods: The IL23R variants were studied in 164 ALL patients and compared to 175 healthy controls by polymerase chain reac...

Background As COVID-19 immunomodulation has been a part of interest for studies, it found that severe coronavirus disease 2019 (COVID-19) is associated with hyper-inflammatory response and increased levels interleukin-6 (IL-6) interleukin-10 (IL-10). This can progress to cytokine storm syndrome eventually development acute respiratory distress (ARDS). Interleukin-1 receptor antagonist (IL-1RA) ...

X-linked severe combined immunodeficiency (X-SCID) is characterized by an absent or diminished number of T cells and natural-killer (NK) cells with a normal or elevated number of B cells, and results from mutations of the gammac chain. The gammac chain is shared by interleukin-2 (IL-2), IL-4, IL-7, IL-9, and IL-15 receptors. Recently, a survival signal through the IL-7 receptor alpha (IL-7Ralph...

This study was conducted to determine whether single nucleotide polymorphisms (SNPs) in nine genes (human leukocyte antigen (HLA), T cell receptor beta (TCA receptor β), tumor necrosis factor α (TNF α), tumor necrosis factor β (TNF β), apolipoprotein E (APOE), interleukin 7 receptor alpha chain (IL7RA) interleukin 2 receptor alpha chain (IL2RA) myelin basic protein (MBP) and vitamin D receptor ...