Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thic...

We have studied the expression of the 15-lipoxygenase gene in various permanent mammalian cell lines in response to interleukins-4 and -13, and found that none of the cell lines tested expressed 5-, 12- or 15-lipoxygenase when cultured under standard conditions. However, when the lung carcinoma cell line A549 was maintained in the presence of either interleukin for 24 h or more, we observed a m...

Interleukins (ILs) are a major subclass of cytokines acting as molecular messengers playing role in immune system responses via cascade signaling pathways. Belonging to the cytokine family, ILs play crucial theranostics various diseases. Their abnormal expression leads development diseases such cancer, neurodegenerative diseases, allergies, asthma, autoimmune and other physiological abnormaliti...