نتایج جستجو برای: intermittent drug exposure
تعداد نتایج: 893670 فیلتر نتایج به سال:
Human skin provides a barrier between the host and the physical, chemical, and biological environment. It is also a potential portal of entry for hazardous or infectious agents and a potential target of environmental toxins. Cutaneous vulnerability may take on many forms in the embryo, infant, child, and adolescent. Teratogenic agents may occasionally target skin, as appreciated in the proposed...
OBJECTIVE Increased glucose 6-phosphate dehydrogenase activity has been demonstrated in heart failure. This study sought to assess myocardial glucose 6-phosphate dehydrogenase activity in retraining of the subpulmonary ventricle of adult goats. METHODS Eighteen adult goats were divided into three groups: traditional (fixed banding), sham, and intermittent (adjustable banding, daily 12-hour sy...
1471 Intermittent Hypoxia Elevates Cobalt Levels in Brain—Veasey et al INTRODUCTION Occurring in 3-5% of adults in developed countries, obstructive sleep apnea (OSA) involves intermittent, sleep state-dependent, brief reductions or cessations in ventilation.1 Each disruption is associated with a partial desaturation of hemoglobin followed by reoxygenation. The brain is particularly vulnerable t...
An increasing number of cancers are known to harbor mutations, translocations, or amplifications in the fibroblast growth factor receptor (FGFR) family of kinases. The FGFR inhibitors evaluated in clinical trials to date have shown promise at treating these cancers. Here, we describe PRN1371, an irreversible covalent inhibitor of FGFR1-4 targeting a cysteine within the kinase active site. PRN13...
Chronic ethanol consumption causes structural and functional reorganization in the hippocampus and induces alterations in the gene expression of gamma-aminobutyric acid type A receptors (GABAARs). Distinct forced intermittent exposure models have been used previously to investigate changes in GABAAR expression, with contrasting results. Here, we used repeated cycles of a Chronic Intermittent Et...
PURPOSE Adaptation to acutely intermittent hypoxic exposure appears to produce worthwhile enhancements in endurance performance, but the current 5-min duration of hypoxia and recovery intervals may not be optimal. METHODS Eighteen male competitive cyclists and triathletes were randomized to one of two intermittent-hypoxia groups, and nine similar athletes represented a control group. Athletes...
A 3-year-old Nigerian boy was treated with phenobarbitone after having a nonfebrile seizure. Two weeks later his urine was found to contain porphobilinogen, indicating that latent acute intermittent porphyria had been unmasked by phenobarbitone. The drug was discontinued and carbamazepine was substituted. The urine became free of porphobilinogen and the patient remained well. In developing coun...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید