Study aims to design a Gastro retentive Drug Delivery System of Cefuroxime axetil (CA). CA is a broad spectrum beta lactam type of antibiotic. More specifically, it is a second-generation cephalosporin. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of ant...

in the long-term management of ulcerative colitis patients, repeat dosing maybe required. since 5-asa is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. the aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-asa deliver...

Effective oral delivery of protein and peptide drugs remains an active topic in scientific research. In this study, matrix type microspheres were prepared with Eudragit® L100 containing N-trimethylchitosan chloride to improve the permeation of insulin across the intestinal epithelium via the paracellular pathway. Insulin loaded microspheres were initially formulated in accordance with a factori...

rug delivery to the colon is beneficial not only for the oral delivery of proteins and peptide drugs (degraded by digestive enzymes of stomach and small intestine) but also for the delivery of low molecular weight compounds used to treat diseases associated with the colon or large intestine such as ulcerative colitis, diarrhea, and colon cancer. In addition, the colon has a long retention time ...

in this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (plga 50:50) and poly (lactide). the effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation efficiency...

mucosa-adhesive gels can be used as a useful mean of delivering drugs to or via mucosal membranes, and in particular buccal mucosa. carbomers are among the best mucosa-adhesive materials known. the aim of this study was to compare the results obtained from the mucosa-adhesive strength of aqueous gels containing carbomers, either alone or in combination, to the data obtained from assessing the d...

orally disintegrating tablets (odts) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. the aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...

abstractgene therapy is a therapeutic approach to deliver genetic material into cells to alter their function in entire organism. one promising form of gene delivery system (dds) is liposomes. the success of liposome-mediated gene delivery is a multifactorial issue and well-designed liposomal systems might lead to optimized gene transfection particularly in vivo. liposomal gene delivery systems...

the present work was aimed to design and develop self-nanoemulsifying drug delivery systems (snedds) with the objective to overcome the problems associated with the delivery of talinolol, a hydrophobic and poorly bioavailable drugs having ph dependant solubility. the solubility of talinolol in various oils, surfactants, cosurfactants and aqueous phases were determined to identify and select the...

in the present study, floating drug delivery beads (fdds) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. in order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the consti...