BACKGROUND Due to its confirmed neuroprotective properties, sevoflurane is one of a few anaesthetics used for neuroanaesthesia. Its effects on the cerebral and systemic circulations may be of particular importance in patientswith intracranial pathology. This study aimed to evaluate the effect of sevoflurane at concentrations lower than 1 MAC on cerebral perfusion pressure (CPP) in patients with...

Editor’s key points † Several factors that influence intracranial pressure (ICP) also influence intraocular pressure (IOP). † Injections into the epidural space can cause cerebrospinal fluid shifts into the cranial space. † This has the potential to increase ICP and IOP. † The authors studied the effect of cervical epidural injections (14 ml) on IOP. Background. Cervical epidural injection (CEI...

Exposure to microgravity causes a bulk fluid shift toward the head, with concomitant changes in blood volume/pressure, and intraocular pressure (IOP). These and other factors, such as intracranial pressure (ICP) changes, are suspected to be involved in the degradation of visual function and ocular anatomical changes exhibited by some astronauts. This is a significant health concern. Here, we de...

BACKGROUND The waveform morphology of intracranial pressure pulses (ICP) is an essential indicator for monitoring, and forecasting critical intracranial and cerebrovascular pathophysiological variations. While current ICP pulse analysis frameworks offer satisfying results on most of the pulses, we observed that the performance of several of them deteriorates significantly on abnormal, or simply...

We evaluated postural effects on intracranial pressure (ICP) and cerebral perfusion pressure [CPP: mean arterial pressure (MAP) - ICP] in neurosurgical patients undergoing 24-h ICP monitoring as part of their diagnostic workup. We identified nine patients (5 women, age 44 ± 20 yr; means ± SD), who were "as normal as possible," i.e., without indication for neurosurgical intervention (e.g., focal...

Intracranial pressure (ICP) is the pressure within the cranium. ICP rise compresses brain vessels and reduces cerebral blood delivery. Massive ICP rise leads to cerebral ischemia, but it is also known to produce hypertension, bradycardia and respiratory irregularities due to a sympatho-adrenal mechanism termed Cushing response. One still unresolved question is whether the Cushing response is a ...

Introduction: In the US, about 60,000 victims of traumatic brain injury (TBI) survive long enough to reach the emergency department (ED). Approximately half of these (30,000) will require careful monitoring of intracranial hypertension [1]. Besides the intracranial pressure (ICP) measurements of TBI patients in the ED, continuous ICP measurements are sometimes essential in terms of managing a p...

OBJECTIVE To assess a newly proposed noninvasive technique for evaluating intracranial pressure (ICP) index and brain compliance (BC) index based on an inverse analysis of a brain-circulation-equivalent electrical circuit (EC) model, in which cerebrospinal fluid (CSF) flow and arterial flow rates measured by using the phase contrast method are used as currents. MATERIALS AND METHODS Quantitat...

OBJECTIVE We investigated the relationship between the intracranial pulse pressure (ICPpp) and the mean intracranial pressure (ICP(M)) in pediatric patients with traumatic brain injury (TBI). METHODS We screened ICP records of 42 patients admitted to the Pediatric Intensive Care Unit at Doernbecher Children's Hospital (OHSU) for segments in which the ICPM varied at least 5 mmHg. We found 54 I...