The dissociation properties of ribosomal RNA from liver and hepatoma were found to be dependent upon the temperature, ionic strength and cationic valency of the solvent. On increasing the temperature the PK values of the N1 H — C 6 = 0 and N1 = C6 — NH2 groups of nucleobases were displaced towards neutrality due to the thermal cleavage of H-bridge linkages. Consequently, as the temperature is i...

Local and Long-Range Electrostatic Interactions in Denatured Ribonuclease Sa: Comparing the Denatured Protein with Model Peptides (April 2002) Michael Douglas Daily Department of Biochemistry and Biophysics Texas A&M University Fellows Advisor: Dr. J. Martin Scholtz Department of Biochemistry and Biophysics The folding ol'proteins into three-dimensional, biologically active conformations demand...